SUMMARY
Background: The antimicrobial properties and molecular interaction analysis of curcumin and its derivatives
against three different strains of Streptococcus pneumoniae (Penicillin-susceptible, Penicillin-intermediate and
Penicillin-resistant) are studied.
Results: These properties were analyzed based on the measurement of the inhibition zone, minimum inhibitory
concentration (MIC), and rate of kill revealed that curcumin monoglucoside, curcumin diglucoside and curcumin
possessed strong antimicrobial properties even on the Penicillin-resistant strains. Additionally, the molecular
docking simulation analyses against Penicillin Binding Protein of S. pneumoniae also confirm that these
compounds docked at the active site of the enzyme. Further, the molecular dynamics simulation validates the
conformational stability of the docked ligand–protein complexes in the dynamic environment.
Conclusion: curcumin monoglucoside, curcumin diglucoside and curcumin can be prescribed for treatment
against Penicillin-resistant S. pneumoniae.