SUMMARY
In aquaculture, fish health problems are often encountered which can lead to failure in cultivation activities. One of the efforts to overcome disease problems in cultivation is carried out by providing immunostimulants. Immunostimulants can increase the immune response of fish, are environmentally friendly and can reduce production costs. Sweet potato leaves are plants that have a short harvest period, are cheap and rich in vitamins and antioxidants. This study was conducted to determine the effect of adding sweet potato leaves to tilapia (Oreochromis niloticus) feed on total leukocytes, hematocrit, and survival rate. The research was conducted by experimental method using a completely randomized design, with 4 treatments and 3 replications. The study was conducted using the dosage of sweet potato used was 0%, 5%, 10% and 15%, which were formulated in fish feed. Based on the results of the study, it can be concluded that sweet potato leaves have a significant effect to total leucosyt where the higher total leucosyt was 6600, but didn’t have a significant effect on the non-specific immune system of tilapia, fagositosis indeks 96,3%, hematocryt count 31% and survival rate 93%.