26 articles in this issue
Dafina Nikolova, Viktorija Chalovska-Ivanova, Magdalena Genadieva-Dimitrova, Aleksandar Eftimov, Rubens Jovanovik, Vesna Janevska (Author)
BACKGROUND: Mutations causing p53 inactivation are among the most common genetic alterations in human malignant tumours including hepatocellular carcinoma. Detection of p53 gene mutations in patients with hepatocellular carcinoma (HCC) should provide rele... see more
Ljubomir Ognjenovikj, Gjorgji Trajkovski, Stojan Gjoshev, Aleksandar Shumkovski, Darko Dzambaz, Dragan Hadzi-Manchev, Goce Volcevski, Igor Fildishevski, Dafina Nikolova, Gordana Petrushevska, Vesna Janevska, Vlado Janevski (Author)
BACKGROUND: HER2 protein expression in gastric carcinoma, in correlation with existing, acknowledged prognostic factors which include the parameters that determine the TNM stage of the disease, could become the basis for ongoing research in the field of m... see more
Mohamed A. El-Nourya, Mahmoud B. El-Begawyb, Mona E. Morsyc, Ehab M. Al Sherbiny (Author)
AIM: This study aimed to evaluate a new modality of low power laser biostimulation in rat ovaries, in comparison with the conventional medical therapy by clomiphene citrate that depends on up-regulation of the hypothalamic-pituitary-ovarian axis to induce... see more
Noni Novisari Soeroso, Rozaimah Zain-Hamid, Bintang Sinaga, Ahmad Sadewa, Tamsil Syafiuddin, Elisna Syahruddin, Gino Tann, Erna Mutiara (Author)
BACKGROUND: Cytochrome P450 2A6 (CYP2A6) is known as an enzyme which is responsible for the metabolism of chemical compounds.AIM: This study aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine metabolism rates and lung cancer ... see more
Ghassan Hamdan Jameel, Ali Ibrahim Ali AL-Ezzy, Ibrahim H. Mohammed (Author)
OBJECTIVES: To evaluate the Immunomodulatory, apoptosis induction and antitumor effects of aqueous and methanolic extracts of Calvatia craniiformis regarding the size of tumour mass, caspase-8 expression and apoptotic index (AI%) in mice transfected with ... see more
Salma A. A. El-Marasy, Reham M. Abd-Elsalam, Omar A. Ahmed-Farid (Author)
AIM: This study aims to elucidate the possible ameliorative effect of silymarin on scopolamine-induced dementia using the object recognition test (ORT) in rats.METHODS: The study was extended to demonstrate the role of cholinergic activity, oxidative stre... see more
Abdollah Hajivandi, Hamid Reza Ghafarian Shirazi, Seyed Hassan Saadat, Mohammad Chehrazi (Author)
AIM: Verification bias is one of the major problems encountered in diagnostic accuracy studies. It occurs when a standard test performed on a non-representative subsample of subjects which have undergone the diagnostic test. In this study we extend a Baye... see more
Aida Mossaad, Amr Kotb, Moustapha Abdelrahman, Hatem Al Ahmady (Author)
BACKGROUND: Postoperative scarring is a common cause of patients dissatisfaction. Several modalities have been developed to overcome such a problem following surgical repair. Despite precise surgical technique, still, some scars would remain over the time... see more
Atoosa Gharib, Mojgan Forootan, Marjan Sharifzadeh, Saied Abdi, Mohammad Darvishi, Ahmad Eghbali (Author)
BACKGROUND: Gastric reflux is one of the most important causes of the referral of patients to the internal clinic, which in some cases causes problems for patients due to resistance to common treatments. Therefore, timely diagnosis and treatment of this g... see more
Khadijeh Haji Naghi Tehrani (Author)
BACKGROUND: The use of the MRI method has opened up a new perspective on pathogenesis, diagnosis and treatment of brain lesions.AIM: Therefore, this study aimed to evaluate the prevalence of brain subclinical lesions in MRI images of migraine patients.MET... see more
Hafza Tola, Mohammed Abbas, Elsir Abu Alhassan, Nassr Eldin Shrif, Mohammed Rida (Author)
BACKGROUND: The diagnosis of polycystic ovary syndrome (PCOS) is not an easy procedure, as the signs and symptoms are heterogeneous and of undefined aetiology.AIM: This study is aimed to evaluate serum anti-Mullerian hormone (AMH) level and luteinizing ho... see more
Samaneh Kouzegaran, Mohammad Ali Zamani, Reza Faridhosseini, Houshang Rafatpanah, Abdolrahim Rezaee, Hadis Yousefzadeh, Rahman Movahed, Farahzad Jabbari Azad, Hooman Tehrani (Author)
BACKGROUND: Allergic rhinitis is one of the most common allergic diseases and characterised by sneezing, rhinorrhea, nasal congestion and nasopharyngeal itching. Subcutaneous immunotherapy (SCIT) for specific allergens is an effective treatment and induce... see more
Seyedeh Masoumeh Ahmadi, Amir Jalali, Rostam Jalali (Author)
BACKGROUND: Decision making about the type of dialysis in kidney failure is a matter of great importance involving the patients, his/her family, and the health care team. Identifying the factors influencing decision making for undergoing peritoneal dialys... see more
Bilger Çavus, Özge Çaydasi, Ahmet Aktan, Ercan Ayaz (Author)
BACKGROUND: Brucellosis can lead to different clinical pictures such as hepatomegaly, granulomatous liver disease, hepatic abscess, and it can cause mild hepatic transaminase elevation in the laboratory investigations.CASE REPORT: We found out that the et... see more
Georgi Tchernev, Ivanka Temelkova (Author)
BACKGROUND: Innovations in medicine are often due to the simplicity of a certain activity, interaction, even counteraction, or a mistake leading to a subsequent final optimal outcome. Innovations could also be due to conclusions based on targeted clinical... see more
Neville Aquilina, Vincent Bugeja (Author)
BACKGROUND: This case report intends to highlight the importance of safeguarding renal function from rhabdomyolysis in neuroleptic malignant syndrome (NMS) by concomitant administration of parenteral fluids at a high rate together with high doses of paren... see more
Maria Ferrillo, Alessia Villani, Gabriella Fabbrocini, Massimo Mascolo, Matteo Megna, Claudia Costa, Maddalena Napolitano (Author)
BACKGROUND: Subcorneal pustular dermatosis, also known as Sneddon-Wilkinson disease, can be classified as one of the neutrophilic dermatoses together with pyoderma gangrenosum. The development of both SPD and PG in the same patient has rarely been reporte... see more
Tanya Naskova Popova, Atanass Radinov, Konstantin Stavrov, Ivanka Temelkova, Ivan Terziev, Ilia Lozev, Detelina Lukanova, Hristo Mangarov, Uwe Wollina, Georgi Tchernev (Author)
BACKGROUND: Modern drugs could sometimes be a good solution even to problematic patients. The cutaneous and systemic forms of the CD30 positive anaplastic large T-cell lymphoma could often be described as a suitable target for therapy with Brentuximab ved... see more
Neville Aquilina, Vincent Bugeja, Charmaine Zahra (Author)
BACKGROUND: Orbital myositis is an idiopathic, inflammatory, non-infectious condition, typically confined to more than one extraocular muscle and usually targeting young females in their third decade.CASE REPORT: We describe a case of orbital myositis unc... see more
Zorica Nanovic, Biserka Kaeva Jovkovska, Gorica Breskovska, Milena Petrovska (Author)
BACKGROUND: Global tuberculosis (TB) epidemic is being driven to an increasing extent by the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis complex (MTBC). We present a case of primary multidrug-resistant tuberculosis (MDR-TB... see more
Ali Saafan, Mohamed H. Zaazou, Marwa K. Sallam, Osama Mosallam, Heba A. El Danaf (Author)
AIM: To assess the antibacterial competence of 650 nm diode laser, Methylene Blue (MB) and Silver Nano-Particles (Ag NPs) on Streptococcus mutans in biofilm-induced caries models.MATERIAL AND METHODS: One hundred eighty specimens were prepared and equally... see more
Fahad M. Albakri, Navin Ingle, Mansour K. Assery (Author)
BACKGROUND: Malocclusion is defined as irregularity of the teeth or a molar relationship between the dental arches beyond the range of what is accepted as normal.AIM: To determine the prevalence of malocclusion among male school children aged 12-15 years ... see more
Biljana Ilievska-Poposka, Maja Zakoska, Karolina Pilovska-Spasovska, Ljiljana Simonovska, Vladimir Mitreski (Author)
BACKGROUND: Tuberculosis (TB) is a major health problem in penitentiary institutions (prisons), and its prevalence was reported to be multiple times higher compared to that of the general population. Conditions such as overcrowding, malnutrition and limit... see more
Katayoon Vakilian, Sajedeh Molavi, Ahmad Reza Zamani, Masoumeh Goodarzi (Author)
BACKGROUND: Reproductive health programs help women live healthier. Family planning consultation is an important component of reproductive health. A good family planning consultation can increase the use of effective birth control methods and improve the ... see more
Somayeh Lookzadeh, Arda Kiani, Kimia Taghavi, Shirin Kianersi, Habib Emami, Maryam Mirenayat, Atefeh Abedini (Author)
INTRODUCTION: Fatigue is one of the common symptoms of sarcoidosis, which occurs in about 50-70% of patients.AIM: Considering that there are no valid Iranian questionnaires for evaluating fatigue in sarcoidosis, in the present study, for the first time, w... see more
Patience I. Adamu, Pelumi Emmanuel Oguntunde, Hilary I. Okagbue, Olasunmbo O. Agboola (Author)
BACKGROUND: The effect of insurgencies on a nation regarding the economy, education, health and infrastructure cannot be overemphasised.AIM: This research is therefore focused on analysing the incidence of HIV/AIDS disease in states affected by the activi... see more