24 articles in this issue
Ainor Rohmah,Sigit Setyawan,Tri Nugraha Susilawati
Hepatitis B and C Viruses (HBV dan HCV) can cause acute or chronic hepatitis that may develop into fibrosis, cirrhosis, and hepatocarcinoma. Previous studies have reported that hepatocyte damage is mainly due to overactive immune responses rather than vir... see more
Dea Noviana Pramantik,Dwi Aryani
Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and has become a major health problem worldwide. Inflammation plays a vital role in the pathophysiology of COVID-19. System... see more
Acivrida Mega Charisma,Elis Anita Farida,Farida Anwari
Severe dengue virus infection often causes proteinuria through several mechanisms, such as leakage of plasma proteins caused by higher protein filtering in the kidneys. The condition of proteinuria in patients with dengue shock syndrome will affect the ma... see more
Fuad Anshori,Tri Ratnaningsih,Teguh Triyono
Blood donation will reduce iron storage in the body. A high frequency of donations and short interval inter-donations may increase the risk of iron deficiency. In Indonesia, detection of iron deficiency in blood donors is not a routine procedure. Therefor... see more
Alicia Fitri Wulandhany,Dewi Indah Noviana Pratiwi,Noor Muthmainah,Agung Biworo
Beta-lactam antibiotic resistance can occur in ESBL-producing bacteria such as E.coli and K.pneumoniae, which can cause UTI. One of the risk factors for infection is the non-intensive care space density level. The objective of this study was to determine ... see more
Dwi Aryani,Dea Noviana Pramatik
Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Respiratory disorders were the most common sign and symptom of COVID-19. Inflammation on SARS-CoV-2 infection is presumed ... see more
Sylvia Youvella,Adi Koesoema Aman,Nizam Akbar
Vascular Endothelial Growth Factor (VEGF) plays an important role in the process of regeneration and vascular repair. Atherogenesis and angiogenesis contribute to the formation of coronary collateral circulation as an alternative source of blood supply du... see more
Debie Anggraini,Meta Zulyati Oktora
Tuberculosis (TB) is a progressive granulomatous infectious disease caused by Gram-positive acid-resistant bacilli classified in the genus Mycobacterium. Tuberculosis in humans is caused by Mycobacterium tuberculosis (MTB) and it mainly infects the lungs,... see more
Nathalya Dwi Kartikasari,I. G.A.A Putri Sri Rejeki,I Dewa Gede Ugrasena
Acute Lymphoblastic Leukemia (ALL) increases annually and the incidence is mostly found in children. Its high failure rate is due to infection in the induction phase of chemotherapy. One of the strategies is laboratory testing to determine prognostic fact... see more
Erlina Wahyu Elmawati,Dewi Indah Noviana Pratiwi,Noor Muthmainah,Agung Biworo
Extended-Spectrum Beta-Lactamase (ESBL) producing bacteria is a type of resistance that leads to complex management of patients in intensive care due to their resistance to first, second, and third-generation Cephalosporin and monobactam antibiotics. The ... see more
Nuniek Luthy Naftali,MI. Diah Pramudianti,Yuwono Hadisuparto
Acute leukemia is a proliferation of immature cells in the bone marrow that affects peripheral blood or other organs. Inflammation has a vital role in cancer pathophysiology. Inflammation in leukemia occurs through two mechanisms: intrinsic and extrinsic.... see more
Purbosari Lisnaedy,Umi Solekhah Intansari
Systemic Lupus Erythematosus (SLE) is an episodic, chronic autoimmune inflammatory disease characterized by remission and flare phases. Laboratory parameters required to assess the severity of disease activity in SLE include platelet count and platelet in... see more
Ni Made Rindra Hermawathi,Betty Agustina Tambunan,Arifoel Hajat
Blood component transfusion is often used as the primary therapy as it is still considered safe. Platelet Concentrate (PC) transfusion plays a critical role in preventing bleeding in patients with severe thrombocytopenia. Allergic reactions are the most f... see more
Sari Amalia,MI. Diah Pramudianti,Yuwono Hadisuparto
Diabetes mellitus type-2 is a transformation of insulin function in peripheral tissues or disorders of pancreatic ß cells. The combination of glycation and glucose oxidation in type 2 DM patients results in the formation of AGEs which can result in oxidat... see more
I Nyoman Gde Sudana,Windarwati Windarwati,Budi Mulyono
Gestational Diabetes Mellitus (GDM) is glucose intolerance during pregnancy. Adiponectin causes a decrease in glucose transporter 4 translocation, which reduces glucose uptake due to downstream insulin signal delivery and decreases non-esterified fatty ac... see more
Rina Erlina,Puspa Wardhani,Yessy Puspitasari,Ulfa Kholili
Liver fibrosis is a complication of chronic hepatitis B. Early detection of liver fibrosis is important for therapy. The aspartate aminotransferase index (AST)-to-platelet ratio index (APRI) and the fibrosis index based on 4 factors (FIB-4) in chronic hep... see more
Sri Mulyani,MI. Diah Pramudianti,Dian Ariningrum
Incidence of thyroid dysfunction increases in HIV/AIDS patients. It can be a hypothyroid or hyperthyroid, with subclinical hypothyroid predomination. Thyroid dysfunction is associated with the progression of HIV and low CD4 counts. There has been controve... see more
Rikarni Rikarni
Pancreatic cancer is the eleventh cause of cancer death in Indonesia in 2020. However, pancreatic cancer is the second leading cause of cancer death in the United States after lung cancer. Although it is substantially less common than the other malignanci... see more
Suryani Jamal,Liong Boy Kurniawan,suci aprianti,Ratna Dewi Artati,Ruland DN Pakasi,R Satriono
Precocious puberty is defined as the onset of secondary sexual characteristics before 8 years of age in girls and 9 years in boys. Central Precocious Puberty (CPP) is caused by early activation of the hypothalamic-pituitary-gonadal axis. Laboratory test o... see more
Anindita Novia Damayanti,Arifoel Hajat
Hairy Cell Leukemia (HCL) is a lymphoproliferative B cell abnormality dominated by mature lymphocytes with cytoplasmic projections and often misunderstood as Chronic Lymphocytic Leukemia (CLL). Misdiagnosis can be caused by errors in the preparation of pe... see more