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1.461.701  Articles
1 of 146.171 pages  |  10  records  |  more records»
The presence of the antibacterial and antifungal activity in derivatives of amino acids is determined by different mechanisms; therefore, a promising field of research is to obtain new N-substituted amino acids and study their antibacterial action.

The concept of “drug likeness” is used when developing drugs for a potential biologically active substance, which must meet some specific criteria, in particular it should be bioavailable. The traditional method of “drug likeness” assessment is verificati... see more

The concept of “drug likeness” is used when developing drugs for a potential biologically active substance, which must meet some specific criteria, in particular it should be bioavailable. The traditional method of “drug likeness” assessment is verificati... see more

Analysis of scientific and patent literature shows the promising results of searching biologically active compounds among derivatives of aromatic aminoacids. For many years at the Medical Chemistry department of the National University of Pharmacy the res... see more

Analysis of scientific and patent literature shows the promising results of searching biologically active compounds among derivatives of aromatic aminoacids. For many years at the Medical Chemistry department of the National University of Pharmacy the res... see more

A theoretical study was conducted to determine the ionization constants of N-substituted amino acid derivatives using HF, DFT, and MP2 calculation methods. The extent of compatibility of these methods was determined by discussing the theoretical variables... see more

Conclusions. In the pathogenesis of cardiovascular, gastroenterological, neurological diseases a significant role is given to amino acids. The analysis of the literature data confirms the rationality of the introduction of drugs containing branched-chain ... see more

The latest published data on heterocyclization of amides of alkenylcarboxylic acids have been systematized. It has been proven that the electrophilic intramolecular cyclization reaction of functionally substituted olefins opened in the 70s of the las... see more

N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl] amino acids reactive ability was investigated at reversible conditions by studying their acid-base properties in binary dioxane-water (60 volume % of dioxane) solvent at 25°C. The experimental compounds were proven... see more

1 of 146.171 pages  |  10  records  |  more records»