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36  Articles
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[2+3] Dipolar cycloadditions of aromatic nitrile oxides to abietic acid esters were investigated. The reactions showed complete site selectivity and regioselectivity, while the stereoselectivity depended on the structures of the dipolarophiles.

The formal [2+2] cycloaddition of ketenes and imines, also known as Staudinger synthesis, is a facile method for the synthesis of biologically important ß-lactam derivatives. In this paper two previously reported stereoselective reactions were investigate... see more

West Nile virus (WNV) is among the other four flavivirus genus, rapidly spreading worldwide. The number of cases increases globally as there are no clinically available approved drugs and vaccines against this disease. Based on our previous finding relate... see more

A simple glance at FDA databases reveals the structural significance of nitrogen-based heterocycles in the drug design and engineering of pharmaceuticals, with nearly 60 % of unique small-molecule drugs containing a nitrogen heterocycle. Many heteroc... see more

Les approches relatives à la synthèse organique, fondées sur des réactions de cycloaddition ont pris ces dernières années une importance considérable. En effet la synthèse des composés hétérocycliques à cinq chainons tels que les isoxazolidines fait souve... see more

Aim. To extend the synthetic limits of the reaction of the electrophilic intramolecular cyclization (EIC) on the examples of 5,5-disubstituted and 5-yliden substituted 3-allyl-2-thiohydantoins and the directed structural modification of 2-halogenomethyl-2... see more

Novel 1,3-oxazepine derivatives have been synthesis via (2+5) cycloaddition reaction of imines and selected cyclic carboxylic acid anhydrides by refluxing in dry benzene. Imines have been prepared by thermal condensation of 4-methyl aniline and para subst... see more

In our previous researches we have shown, that 1-aminoisoindole, which exists predominantly in isoindoline tautomeric form, can undergo [4+2]-cycloaddition reactions with maleimides according to the Curtin-Hammet principle. We continued to study this reac... see more

Novel 1,3-oxazepine derivatives have been synthesis via (2+5) cycloaddition reaction of imines and selected cyclic carboxylic acid anhydrides by refluxing in dry benzene. Imines have been prepared by thermal condensation of 4-methyl aniline and para subst... see more

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