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63  Articles
1 of 7 pages  |  10  records  |  more records»
Five stable isomers of antiviral ribavirin agent were theoretically determined in gas and aqueous solution by using the hybrid B3LYP/6-31G* method. Here, the solvent effects were studied with the self consistent reaction field (SCRF) methodology employing... see more

ABSTRACT. Viana K.F. & Teixeira N.S. [Ribavirin and nervous distemper phase: clinical cure, but not sterilizing- Report of two cases.] Ribavirina e fase nervosa da cinomose: cura clínica, mas não esterilizante - Relato de dois casos. Revista Brasileira de... see more

Clinical trials evaluating the safety and efficacy of daclatasvir for chronic hepatitis C virus (HCV) genotype 4 infection are scarce and yet with small sample sizes. Therefore, we conducted this systematic review to investigate the efficacy of daclatasvi... see more

BACKGROUND: Chronic hepatitis C virus infection represents a more frequent cause of liver cirrhosis and hepatocellular carcinoma. Statins, inhibit HCV replication in vitro, enhance the antiviral effect of the already known antiviral drugs and reduce their... see more

Background: The presence of direct-acting antiviral (DAA) has improved the treatment of HCV infection and making it more preferable than Pegylated-interferon (PegIFN) and Ribavirin (RBV) based treatment. However, treatment with all DAA combination regimen... see more

Paper description: Ribavirin is an antiviral agent showing side effects associated with use of high doses and/or long-term application.This study examined the effects of single or repeated application of low ribavirin doses (10, 20 and 30 mg/kg/day, i.p.)... see more

Objective: To assess the effectiveness of Sofosbuvir (SOF) and Daclatasvir (DCV) in patients with chronic hepatitis C (CHC), compensated cirrhosis (CC) and decompensated cirrhosis (DCLD) either treatment naïve or experienced.Methods: This was a prospectiv... see more

Aim. To synthesize, prove the structural framework and study the antiviral activity of 1-(4-chlorophenyl)-4-(para-tolyl)-5,6,7,8-tetrahydro-2a,4a-diazacyclopenta[cd]azulene-2-carboxylic acid derivatives.Results and discussion. The antiviral activity of 1-... see more

Sofosbuvir in combination with peginterferon and ribavirin for 12 weeks is a new treatment paradigm with a 12 week course of therapy leading to high sustained response rates in genotype 1 and 4  infected individuals including high sustained response ... see more

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