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7.499  Articles
1 of 751 pages  |  10  records  |  more records»
Thalassemia major is one of the types of thalassemia that need a routine blood transfusion. If not treated immediately, the patient will only last for 1-8 months. Blood transfusions performed at least or more than 10 times causes iron overload. Excess lev... see more

Background: Cardiac failure secondary to transfusional iron overload is the most common cause of death in patients with thalassemia. Earlydetection of myocardial iron deposition is necessary to prevent overt heart failure. Objective: Assessment of myocard... see more

Introduction: There are certain risk factors or predictors that can be used for early detection of cardiac iron overload to improve the long-term gains in beta-thalassemic children. Objective: The aim of the study was to consider the predictive abilities ... see more

 
Regular blood transfusions is a lifetime treatment for blood disorder such as thalassemia and it can lead to the iron accumulation within the organs. Iron accumulation in the brain can cause toxicity by increasing reactive oxygen species (ROS) and alterin... see more

Thalassemia patients who receive repeated blood transfusions are at risk of iron overload and hepatitis C infection. Iron overload cancause iron deposit in many organs, including the liver. Iron deposits in the liver and hepatitis C infection can cause ch... see more

AIM: This study aimed to detect the most common HFE gene mutations (C282Y, H63D, and S56C) in Egyptian beta thalassemia major patients and its relation to their iron status. SUBJECTS AND METHODS: The study included 50 beta thalassemia major patients and 3... see more

BACKGROUND: Beta Thalassemia is the most common chronic hemolytic anemia in Egypt (85.1%) with an estimated carrier rate of 9-10.2%. Injury to the liver, whether acute or chronic, eventually results in an increase in serum concentrations of Alanine transa... see more

BACKGROUND: Thalassaemia is a hereditary disorder and has an economic burden on patients and the government. The most prevalent complication in these patients is iron overload which is followed by cardiomyopathy. Digoxin is considered as a treatment again... see more

BACKGROUND: Plasma iron excess can lead to iron accumulation in heart, kidney and liver. Heart failure is a clinical widespread syndrome. In thalassemia, iron overload cardiomyopathy is caused by iron accumulation in the heart that leads to cardiac damage... see more

1 of 751 pages  |  10  records  |  more records»