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250  Articles
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In this study, we observed the therapeutic effects of acupuncture and investigated the underlying molecular mechanisms by constructed a hypoxic-ischemic encephalopathy (HIE) animal model. In the electroacupuncture group, mTOR expression increased since 1d... see more

Background: Fisetin, a natural potent flavonoid, has various beneficial, pharmacological activities. In this study, we investigated expression changes of the fisetin regulating genes in lipopolysaccharide (LPS)-treated RAW264.7 cells and explored the role... see more

Batik has been acknowledged as a Masterpiece of Oral and Intangible Heritage of Humanity of Indonesia based on UNESCO in 2009 and this asset is considerably becoming the prospect to overcome global market in Asia. In the other side, the global competition... see more

Background: Browning of white adipose tissues (WAT) is recognized as a novel way to combat obesity and its related comorbidities. Thus, a lot of dietary agents contributing to browning of WAT have been identified.Objective: In this study, we try to explor... see more

We consider a combined MTS-MTO supply chain in which an MTO manufacturer replenishes component inventory from contract suppliers on a MTS basis. Two types of component replenishment strategies are evaluated; multiple suppliers with a fixed order quantity ... see more

Introdução: O exercício físico resistido agudo e crônico tem como característica a realização de estímulos de curta duração com séries repetidas contra uma resistência, além de ser um potente estímulo à síntese proteica do músculo esquelético. Esta altera... see more

Despite advances in conventional therapies, treatment of prostate cancer is still a challenge. The study aims to assess the possible anti-cancer effects of tangeretin, a dietary flavonoid on human prostate cancer cells (DU145, PC3, LNCaP). Tangeretin (25,... see more

Cadmium, a toxic environmental contaminant, induces oxidative stress leading to various neurodegenerative disorders, where it interferes with homeos-tasis of intracellular free calcium ([Ca2+]i), leading to cellular damage and apoptosis. We investigated w... see more

The first compound that inhibited the mammalian target of rapamycin (mTOR), sirolimus (rapamycin) was discovered in the 1970s as a soil bacterium metabolite collected on Easter Island (Rapa Nui). Because sirolimus showed antiproliferative activity, resear... see more

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