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6.138  Articles
1 of 615 pages  |  10  records  |  more records»
Among the various fluorescent probes currently used for biomedical and biochemical studies, significant attention attracts cyanine dyes possessing advantageous properties upon their complexation with biomolecules, particularly nucleic acids. Given the wid... see more

The aggregation of misfolded proteins into specific ordered aggregates, amyloid fibrils, associated with more than forty human diseases, currently attracts great research attention in biomedical and nanotechnological aspects. These aggregates and their ol... see more

Due to their unique photophysical and photochemical properties and high sensitivity to the beta-pleated motifs, cyanine dyes have found numerical applications as molecular probes for the identification and characterization of amyloid fibrils in vitro and ... see more

Protein aggregation into highly ordered supramolecular aggregates is the hallmark of many degenerative diseases including the neurological disorders (Parkinson’s, Alzheimer’s, and Huntington’s diseases), type II diabetes, systemic amyloidosis, spongiform ... see more

The co-localization of the donor and acceptor fluorophores capable of transferring the energy by the F?rster mechanism, on the molecular scaffold of amyloid fibrils offers new opportunities not only for refinement of the amyloid detection and structural a... see more

Molecular interactions between novel monomethine cyanine dyes and non-fibrilar and fibrilar proteins were assessed using fluorescence spectroscopy and molecular docking techniques. To this end, the fluorescence spectral properties of dyes have been explor... see more

Self-assembly of proteins and peptides into amyloid fibrils is the subject of intense research due to association of this process with multiple human disorders. Despite considerable progress in understanding the nature of amyloid cytotoxicity, the role of... see more

Human insulin, a small protein hormone consisting of A-chain (21 residues) and B-chain (30 residues) linked by three disulfide bonds, is crucial for controlling the hyperglycemia in type I diabetes. In the present work molecular dynamics simulation (MD) w... see more

The applicability of the three-step Förster resonance energy transfer (FRET) to detection of insulin amyloid fibrils was evaluated, using the chromophore system, containing Thioflavin T (ThT), 4-dimethylaminochalcone (DMC), and two squaraine dyes, referre... see more

1 of 615 pages  |  10  records  |  more records»