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225  Articles
1 of 23 pages  |  10  records  |  more records»
Due to their unique photophysical and photochemical properties and high sensitivity to the beta-pleated motifs, cyanine dyes have found numerical applications as molecular probes for the identification and characterization of amyloid fibrils in vitro and ... see more

Protein aggregation into highly ordered supramolecular aggregates is the hallmark of many degenerative diseases including the neurological disorders (Parkinson’s, Alzheimer’s, and Huntington’s diseases), type II diabetes, systemic amyloidosis, spongiform ... see more

Molecular interactions between novel monomethine cyanine dyes and non-fibrilar and fibrilar proteins were assessed using fluorescence spectroscopy and molecular docking techniques. To this end, the fluorescence spectral properties of dyes have been explor... see more

Self-assembly of proteins and peptides into amyloid fibrils is the subject of intense research due to association of this process with multiple human disorders. Despite considerable progress in understanding the nature of amyloid cytotoxicity, the role of... see more

The aim of this study was to assess the potential of amyloid precursor protein in peripheral granulocytes as a diagnostic biomarker for early detection of Alzheimer's disease. Immunohistochemistry and flow cytometry were used to evaluate amyloid precursor... see more

Curcumin, a polyphenolic compound, derived from the rhizomes of Curcuma longa L. Curcumin shows potential pharmacological action against numerous disorders, including cancer, neurodegenerative, and infection diseases. Curcumin-based molecular imaging agen... see more

Alzheimer’s disease (AD) belongs to the class of neurodegenerative disorder and is biochemically characterized by amyloid-ß (Aß) plaques deposition, accumulation of neurofibrillary tangles (NFTs) accumulation and ultimately neuronal loss. Even though, the... see more

 
Alzheimer’s disease (AD) is a brain disease attributed to the accumulation of extracellular senile plaques comprising ß-amyloid peptide (Aß). In this study, a transgenic Caenorhabditis elegans (C. elegans) containing the human beta amyloid Aß42 gene which... see more

The binding of the benzanthrone dye ABM to the model amyloid fibrils of human insulin, referred to here as vealyl (12-VEALYL-17, insulin B-chain)), lyqlen (13-LYQLEN-18, insulin A-chain) and Insf ( 11-LVEALYL-17, B-chain) + 12-SLYQLENY-19, A-chain) was st... see more

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