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1.978.410  Articles
1 of 197.841 pages  |  10  records  |  more records»
The article describes the study of the antihypoxic action of the compounds previously synthesized, namely indole and 2-oxindole derivatives, containing an ethylamine fragment being characteristic of melatonin, and the “chemical structure – antihypoxic act... see more

Modification of the spiro-2-oxindole skeleton due to introduction of pharmacophores of the known biologically active substances is a productive way for searching and creating new biologically active molecules with the non-planar structure.

Currently, antibiotic resistance is becoming a tremendous threat in treatment of bacterial and fungal infections. Therefore, a topical question is the search of new classes of antimicrobial drugs. The present article is devoted to the study of antimicrobi... see more

Currently, antibiotic resistance is becoming a tremendous threat in treatment of bacterial and fungal infections. Therefore, a topical question is the search of new classes of antimicrobial drugs. The present article is devoted to the study of antimicrobi... see more

Aim. To synthesize the series of new spiro[indole-3,1’-pyrrolo[3,4-c]pyrrole]-2,4’,6’-trione derivatives, study their physicochemical characteristics, antibacterial activity and precision of the molecular docking on the model of staphylococcal dehydrosqua... see more

A convenient and efficient method for the synthesis of new unsaturated spiro-annulated N-aryl-4,6-dioxopyrimidine-2-thione derivatives has been developed. The resulting compounds can be potential biological active molecules or precursors for further chemi... see more

The present article describes the synthesis of novel spiro-condensed [1,2,4]triazolo[1,5-c]quinazolines. [2-(3-Aryl1H-1,2,4-triazol-5-yl)phenyl]amines were used as effective precursors for the synthesis of the compounds mentioned above. The experimental d... see more

Aim. To synthesize the series of new spiro[indole-3,1’-pyrrolo[3,4-c]pyrrole]-2,4’,6’-trione derivatives, study their physicochemical characteristics, antibacterial activity and precision of the molecular docking on the model of staphylococcal dehydrosqua... see more

The development of medicines with several pharmacological activities, including the analgesic, anti-inflammatory and antimicrobial properties, is one of the challenging tasks of modern medicinal chemistry.Aim. To expand the range of novel spiro-condensed ... see more

1 of 197.841 pages  |  10  records  |  more records»