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13  Articles
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A method, probably the best one, to improve anticancer drugs permeability isstructural modification on the base of “drug-likeness” fundamental concepts in the way of reducingionizability and polarity, reducing number of hydrogen bond donors or acceptors a... see more

Triple-negative breast cancer (TNBC) accounts for approx. 10–20% of breast cancer diagnoses worldwide. Triple-negative breast cancer cells have no estrogen nor progesterone receptors and lack overexpression of human epidermal growth factor receptor. As no... see more

Anthracycline-based neoadjuvant chemotherapy is the recommended therapy for locally advanced breast cancer (LABC) patients. Unfortunately, no study has reported the relationship between body mass index (BMI), total lymphocyte count (TLC), and responses to... see more

Trastuzumab, a humanized monoclonal antibody against the extracellular domain of human epidermal growth factor receptor 2 (HER-2) prolongs disease-free survival (DFS) and overall survival (OS) in patients with early-stage breast cancer. Although it is gen... see more

Introduction. Anthracyclines are among the most effective anti-cancer and cytotoxic drugs along years. Unfortunately, over the years, its cardiotoxic effects and irreversible heart damage with followed congestive heart failure is still unresolved problem ... see more

Introdução: As doenças cardiovasculares são uma complicação importante em pacientes em tratamento antineoplásico. Inúmeros agentes quimioterapêuticos podem causar lesões reversíveis ou irreversíveis nas células cardíacas, deixando a disfunção cardiomiócit... see more

The development of new methods of treating patients with breast cancer (BC) causes no doubts at anyone at present moment. The statistical data testify to steady growth of BC sickness rate during recent 20 years without tendency to stabilization The specia... see more

Anthracycline antitumor antibiotics are widely used for the treatment of malignancies, but this group of drugs is known for their cytotoxic effects, especially cardiotoxicity. It has been proven that the adverse effect of anthracyclines on tissues is base... see more

Introduction. Anthracyclines are among the most effective anti-cancer and cytotoxic drugs along years. Unfortunately, over the years, its cardiotoxic effects and irreversible heart damage with followed congestive heart failure is still unresolved problem ... see more

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