ARTICLE
TITLE

A Dual-Aggressive Model of Tumor-Immune System Interactions

SUMMARY

Biomedical literature suggested that the tumor-immune system physical phenomenon usually climaxes into either tumor elimination or escape. In retort to the phenomenological mechanics of tumor-immune system interaction, researchers had used Mathematical models mostly prey-predator and competitive extensively, to model the dynamics of tumor immune system interaction. However, these models had not accounted for total elimination and, or escape of tumor as hypothesizes by immunoediting hypotheses. In this work, we propose a dual aggressive model based on the biological narration of tumor-immune system interactions. The stability analyses of tumor-negative steady state are stable if the rate at which body cells dies is less than their proliferation rate a confirmation of biological listed causes of the tumor. The tumor-positive steady state is always unstable and saddle with the likelihood of either elimination or escape of tumor. Numerical analysis validates our analytical results and provides insight into the dynamics of the benignant and malignant tumor. The immunosuppression by tumor is not only visible but also validated by both analytical and numerical analysis.

 Articles related

Gloria Mittica, Sofia Genta, Massimo Aglietta and Giorgio Valabrega    

Epithelial ovarian cancer (EOC) is the leading cause of death for gynecological cancer. The standard treatment for advanced stage is the combination of optimal debulking surgery and platinum-based chemotherapy. Nevertheless, recurrence is frequent (aroun... see more


Alessandro Passardi, Matteo Canale, Martina Valgiusti and Paola Ulivi    

Anti-tumor immunity is a new line of research for the treatment of patients with solid tumors. In this field, negative regulators of the immune system called immune checkpoints play a key role in limiting antitumor immunologic responses. For this reason,... see more


Daniel H. Ahn, Ramesh K. Ramanathan and Tanios Bekaii-Saab    

Pancreatic adenocarcinoma is typically refractory to conventional treatments and associated with poor prognosis. While therapeutic advances over the past several years have improved patient outcomes, the observed benefits have been modest at best, highli... see more

Revista: Cancers

Soetjipto Soetjipto,Indri Dwi Murbani,Titut Harnanik    

BACKGROUND: Lupus nephritis (LN) is associated with chronic renal failure and a high mortality rate. Tumor growth factor-ß (TGF-ß) plays a basic part in keeping up immune homeostasis, meanwhile extensive oxidation of the lipid membrane in LN causes the a... see more


Anna Meiliana,Nurrani Mustika Dewi,Andi Wijaya    

BACKGROUND: Metastases are simply known as cancers spread to another part of the body, and often be responsible for the severity of cancer prognosis. Somehow, the complex mechanisms of metastases are not fully understood yet.CONTENT: The characteristic o... see more