SUMMARY
Introduction. Caries is the most common pathology in the world, which significantly affects not only dental but also somatic health.The aim of the study – to evaluate the effectiveness of the preventive complex for caries under puberty in Wistar rats.Research Methods. The experiment was conducted on the basis of the vivarium of the State University “IS NAMNU” on 40 white rats of the Wistar herd breeding line (males, 1 month old, weight 53–68 g). The animals were divided into 4 groups, 10 rats each: group 1 – intact control on a vivarium diet; group 2 – cariogenic diet; group 3 – cariogenic diet + NaNO3 250 mg/l; group 4 – cariogenic diet + NaNO3 + prophylactic complex. The preventive complex consisted of preparations administered intragastrically daily: “Quercetin granules with pectin” 500 mg/kg and a complex of vitamins and minerals “Alphabet schoolboy” 150 mg/kg. In the morning, the rats were brushed with R.O.C.S. paste, and at the end of the day, ROCS gel applications on the teeth were administrated.Results and Discussion. The content of young rats on Stefan's diet led to inhibition of the increase in body weight of animals, the development of the carious process, the intensification of inflammation in the oral cavity and the body, accompanied by the activation of resorption processes in the hard tissues of the teeth and bone tissue of the jaw against the background of a decrease in non-specific antimicrobial protection in the oral cavity and pulp animal teeth. Long-term consumption of drinking water containing 5 MPC nitrates, in combination with a cariogenic diet, intensified the above processes in rats. In addition, in animals with an additional nitrate load, an increase in the degree of atrophy of the alveolar bone of the lower jaw, a slowdown in the synthetic processes in the pulp and bone tissue of the jaw, a decrease in the level of calcium in the jaws, and an increase in “liver” markers in the blood serum were found. Conducting daily prophylaxis with quercetin and pectin, a complex of vitamins and minerals in combination with hygiene means for the oral cavity R.O.C.S. effectively prevented the negative effects of cariogenic diet and nitrates.Conclusion. The effectiveness of the preventive complex for leveling adverse cariogenic effects has been confirmed in experimental conditions.