SUMMARY
It has been found, that all experimental samples of the developed syrups after adding the selected preservatives are promising for the further research in area of oral remedies creation. Nevertheless, the antimicrobial effectiveness of Potassium sorbate is slightly higher (lg of reducing the number for Candida albicans ???? 885-653 viable cells is 3.55; for Aspergillus brasiliensis ???? 16404 is 2,3), and antimicrobial activity spectrum is wider, which will promote the quality of the developed syrup, as well as during its storage period. Therefore, Potassium sorbate will be used as a preservative in the following research.Results. The advisability of using of Potassium sorbate as a preservative in development of the combined syrup basis with complex pharmacological activity was theoretically substantiated and experimentally proved