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Alessandro Zenobi,Fulvio Gandolfi,Tiziana Angela Luisa Brevini    

In vivo, cells are surrounded by a three-dimensional (3-D) organization of supporting matrix, neighboring cells and a gradient of chemical and mechanical signals (Antoni, et al., 2015). However, the present understanding of many biological processes is m... see more


Deni Zulfiana    

Acute oral and dermal toxicity test against white rats was conducted to determine the toxicity and side effects of bio-larvacide (Metarhizium anisopliae crude extract) on humans. In the oral test used a maximum dose 5000 mg/kg and dermal testing used a m... see more


S Montagnani, L Postiglione, G Giordano-Lanza, F Di Meglio, C Castaldo, S Sciorio, N Montuori, G Di Spigna, P Ladogana, A Oriente, G Rossi    

Fibroblasts are involved in all pathologies characterized by increased ExtraCellularMatrix synthesis, from wound healing to fibrosis. Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a cytokine isolated as an hemopoietic growth factor but rec... see more


Maria Vianny Sansan,Sunardi Radiono,Muhamad Eko Irawanto,Yohanes Widodo Wirohadidjojo    

The most influential factor in the poor healing of chronic ulcers is replicative senescence of fibroblasts that are unresponsive to TGF-ß1 stimulation. Cellular replicative senescence can be induced by cultivating normal human dermal fibroblasts (HDFs) i... see more


Francesca Giampieri, Massimiliano Gasparrini, Tamara Y. Forbes-Hernández, Piera Pia Manna, Jiaojiao Zhang, Patricia Reboredo-Rodríguez, Danila Cianciosi, Jose L. Quiles, Cristina Torres Fernández-Piñar, Francisco Josè Orantes-Bermejo, Stefano Bompadre, Sadia Afrin and Maurizio Battino    

The antioxidant capacity and the phytochemical composition of two by-products from beeswax recycling processes were recently investigated. The aim of the present work was to evaluate the efficacy of one of these by-products, MUD1, against the oxidative s... see more