ARTICLE
TITLE

Changing of dynamic response of the active muscle soleus in conditions of its ischemization in alcoholic rats when C60 fullerene is administered

SUMMARY

There were studied the effects of bio-compatible nanostructures ?60 on mechanisms of muscle soleus contractions in alcoholized rats at their ischemic lesion for estimating the therapeutic effect of fullerene ?60 on the time development of general pathogenesis in the ischemically injured muscular system.The obtained data testify to the expressed protective effect of ?60FAS on the dynamics of muscle soleus contractions in alcocholized rats at their ischemic lesion. It indicates the fact that ?60FAS may be considered as promising medical means for prophylaxis and correction of the ischemically injured muscle.The studies demonstrated that administration of ?60FAS causes different therapeutic effects on different zones of the contraction process.   It was demonstrated, that the use of the water solution of fullerenes in dose 1 mg/kg as a protector on dynamic characteristics of skeletal muscles is effective at initial stages of lesions that is at ischemia during 1 hour. At increasing the ischemia duration, the protective influence of the solution decreases that may be connected with irreversible lesions in skeletal muscles, caused by the synergetic effect of two pathologies

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