Biomolecules  

Biomolecules Editorial Office

Rigorous peer-review is the cornerstone of high-quality academic publishing [...]

Andreas Hähle, Stephanie Merz, Christian Meyners and Felix Hausch

The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and... see more

Saikat Kumar Poddar, Ali Ehsan Sifat, Sanjana Haque, Noor Ahmed Nahid, Sabiha Chowdhury and Imtias Mehedi

Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis. Although the biosynthetic pathway of NMN varies between eukaryote and prokaryote, two pathw... see more

Santosh Lamichhane, Linda Ahonen, Thomas Sparholt Dyrlund, Alex M. Dickens, Heli Siljander, Heikki Hyöty, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Tuulia Hyötyläinen, Mikael Knip and Matej Oresic

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Hussein J. Hamam, Meraj A. Khan and Nades Palaniyar

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B. Angélica Pilón-Jiménez, Fernanda I. Saldívar-González, Bárbara I. Díaz-Eufracio and José L. Medina-Franco

Compound databases of natural products have a major impact on drug discovery projects and other areas of research. The number of databases in the public domain with compounds with natural origins is increasing. Several countries, Brazil, France, Panama an... see more

Ning Yan, Yongmei Du, Xinmin Liu, Hongbo Zhang, Yanhua Liu and Zhongfeng Zhang

Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural produ... see more

Jeremy D. S. Marshall, Dielle E. Whitecross, Paul Mellor and Deborah H. Anderson

The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in the regulation of cell signaling, proliferation, survival, migration and vesicle trafficking in normal cells and is frequently deregulated in many cancers. The p85α protein is ... see more

Laura Magnaghi-Jaulin, Grégory Eot-Houllier, Emmanuel Gallaud and Régis Giet

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Zheng Yang, Brandon Uhler, Ted Zheng and Kristie M. Adams

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Young Ha Yoon, Minjae Kim and Woong June Park

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Fayez T. Hammad, Suhail Al Salam, Abderrahim Nemmar, Mahmoud Ali and Loay Lubbad

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Esra Demir, Hanise Ozkan, Kerem Doga Seckin, Berrak Sahtiyanci, Bulent Demir, Omur Tabak, Abdülbaki Kumbasar and Hafize Uzun

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Dhawal Choudhary, Alessandro Mossa, Milind Jadhav and Ciro Cecconi

In the past three decades, the ability to optically manipulate biomolecules has spurred a new era of medical and biophysical research. Optical tweezers (OT) have enabled experimenters to trap, sort, and probe cells, as well as discern the structural dynam... see more

Sara Silva, António J. Almeida and Nuno Vale

Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid residues capable of penetrating biological barriers and cellular membranes. Furth... see more

Maria Pereira-Oliveira, Ana Reis-Mendes, Félix Carvalho, Fernando Remião, Maria de Lourdes Bastos and Vera Marisa Costa

Currently, a common therapeutic approach in cancer treatment encompasses a drug combination to attain an overall better efficacy. Unfortunately, it leads to a higher incidence of severe side effects, namely cardiotoxicity. This work aimed to assess the cy... see more

Izailda Barbosa dos Santos and Sang-Wook Park

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Siti Syairah Mohd Mutalip, Mohd Hamim Rajikin, Sharaniza Ab Rahim and Nor-Ashikin Mohamed Noor Khan

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Leidiane de Lucca, Letícia Bigolin Jantsch, Silmara Ana Vendrame, Carolina dos Santos Stein, Vanessa Cristina Grólli Klein, Karina Biaggio Soares, Francisco Maximiliano Pancich Gallarreta, Rafael Noal Moresco and Thissiane de Lima Gonçalves

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Guanghong Han, Jian Zuo and Lexie Shannon Holliday

Osteoclasts are cells of the hematopoietic lineage that are specialized to resorb bone. In osteoclasts, the actin cytoskeleton engages in at least two unusual activities that are required for resorption. First, microfilaments form a dynamic and structural... see more

Sharon Varghese, Samson Mathews Samuel, Elizabeth Varghese, Peter Kubatka and Dietrich Büsselberg

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Boel De Paepe

The sporadic form of inclusion body myositis (IBM) is the most common late-onset myopathy. Its complex pathogenesis includes degenerative, inflammatory and mitochondrial aspects. However, which of those mechanisms are cause and which effect, as well as th... see more

Edyta Wysokinska, Jakub Cichos, Agnieszka Kowalczyk, Miroslaw Karbowiak, Leon Strzadala, Artur Bednarkiewicz and Wojciech Kalas

Gadolinium-doped nanoparticles (NPs) are regarded as promising luminescent probes. In this report, we studied details of toxicity mechanism of low doses of NaGdF4-based fluorescent nanoparticles in activated RAW264.7, J774A.1 macrophages. These cell lines... see more

Akhila Nair, Augustine Amalraj, JoJacob, Ajaikumar B. Kunnumakkara and Sreeraj Gopi

Over the past decades curcuminoids have been extensively studied for their biological activities such as antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic, antifertility, antidiabetic, anticoagulant, antivenom, antioxidant, a... see more

Jie Luo, Wenxiu Xia, Pei Cao, Zheng’ang Xiao, Yan Zhang, Meifeng Liu, Chang Zhan and Nian Wang

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Hagen Klett, Lonny Jürgensen, Patrick Most, Martin Busch, Fabian Günther, Gergana Dobreva, Florian Leuschner, David Hassel, Hauke Busch and Melanie Boerries

Heart diseases are the leading cause of death for the vast majority of people around the world, which is often due to the limited capability of human cardiac regeneration. In contrast, zebrafish have the capacity to fully regenerate their hearts after car... see more

Kinue Kuniyasu, Kenji Iemura and Kozo Tanaka

For appropriate chromosome segregation, kinetochores on sister chromatids have to attach to microtubules from opposite spindle poles (bi-orientation). Chromosome alignment at the spindle equator, referred to as congression, can occur through the attachmen... see more

Alina Chernova, Rim Gubaev, Pavel Mazin, Svetlana Goryunova, Yakov Demurin, Lyudmila Gorlova, Anna Vanushkina, Waltraud Mair, Nikolai Anikanov, Elena Martynova, Denis Goryunov, Sergei Garkusha, Zhanna Mukhina and Philipp Khaytovich

Sunflower and rapeseed are among the most important sources of vegetable oil for food and industry. The main components of vegetable oil are triglycerides (TAGs) (about 97%). Ultra- performance liquid chromatography coupled with mass spectrometry (UPLC&nd... see more

Christophe Bignon, Francesca Troilo, Stefano Gianni and Sonia Longhi

In this paper we review our recent findings on the different interaction mechanisms of the C-terminal domain of the nucleoprotein (N) of measles virus (MeV) NTAIL, a model viral intrinsically disordered protein (IDP), with two of its known binding partner... see more

Sandra F. Gallego, Martin Hermansson, Gerhard Liebisch, Leanne Hodson and Christer S. Ejsing

Total fatty acid analysis is a routine method in many areas, including lipotyping of individuals in personalized medicine, analysis of foodstuffs, and optimization of oil production in biotechnology. This analysis is commonly done by converting fatty acyl... see more