13 articles in this issue
Han Chen, MD,Jing Wang, MD, PhD,Jian-An Wang, MD,Guo-Ping Shi, DSc
Left ventricular remodeling after myocardial infarction (MI) includes extensive cardiac cell death, inflammatory cell infiltration, cell differentiation, and scar formation. Lysosomal proteases cathepsins participate in all these events during post-MI car... see more
Harish Jevallee, MD,Ting-Ting Tang, MD, PhD,Xiang Cheng, MD, PhD
Recent researches have substantiated the active participation of chronic low-grade inflammation in cardiovascular disease where immune responses contribute to disease initiation and progression. Regulatory T cells (Tregs) are a unique lineage of T cells a... see more
Congqing Wu, MS,Hong Lu, MD, PhD,Lisa A. Cassis, PhD,Alan Daugherty, PhD, DSc, FAHA
The renin-angiotensin system is an essential regulatory system for blood pressure and fluid homeostasis. Angiotensinogen is the only known precursor of all the peptides generated in this system. While many of the basic understandings of angiot... see more
Zhuxia Shen, PhD,Mingxing Lu, BS,Shengshu Duan, BS,Shengzhong Duan, MD, PhD
Classically activated macrophages (M1) and alternatively activated macrophages (M2) are induced by Th1 and Th2 cytokines respectively. These macrophages are phenotypically and functionally different. Polarized macrophages are important players in inflamma... see more
Weili Zhang, MD, PhD,Rutai Hui, MD, PhD
Uric acid is the end product of purine metabolism in humans. During the past several decades, lifestyle and dietary changes and the aging of overall population contribute to progressively rising of serum uric acid levels. Although a number of epidemiologi... see more
Jing Liu, MD, MPH,Yuling Hong, MD, PhD,Yue Qi, MD, PhD,Fan Zhao, PhD,Dong Zhao, MD, PhD
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel inflammatory biomarker. Basic research has shown that Lp-PLA2 is involved in the pathogenesis of atherosclerosis. In the past decade, an increasing number of epidemiological studies have investi... see more
Wenjun Zhong, PhD
Dementia is an important public health issue in the ageing society; however the cause of dementia has not been clear yet except for age and genes. Cardiovascular risk factors have been suggested to contribute to dementia, such as high blood pressure, but ... see more
Katherine Bowers, PhD,Cuilin Zhang, MD, PhD
Gestational diabetes is a common pregnancy complication whose prevalence is increasing among women of reproductive age and results in both short-and long-term adverse outcomes for the offspring. Hyperglycemia or other consequences of adverse materna... see more
Qi Zhang, PhD,Liuliu Fu, BS
The consumption of fruits and vegetables (F&V) has a significant protective effect in reducing various cardiometabolic diseases. In recent years, the U.S. government has made a lot of effort to promote F&V consumption through different projects and progra... see more
Yujie Wang, MSc,Gang Hu, MD, PhD
Heart Failure (HF) has become a major public health problem in both developed and developing countries of the world. Although medical and surgical management has been improved, morbidity and mortality after onset of HF remain substantial; consequently, in... see more
Simpal Gill, MD,Frank Chen, MD, PhD
Caseous calcification of the mitral annulus (CCMA) is a rare form of periannular calcification, occurring in 0.06% of all echocardiographic studies and in 0.63% of all patients with mitral annular calcification. Here, we report a case of CCMA manife... see more
Charles DeMesa, DO,Xixi Amley,MD,Pang Lam, MD,Maxine Seales, MD,Joshua Kerstein, MD,Jocob Shani, MD
Mediastinitis is a rare, severe condition associated with increased morbidity and mortality. Mediastinitis, a life-threatening infection, may occur during the postoperative period following cardiovascular surgery. We present a unique case of mediastinitis... see more
Yunsheng Ma, , MD, PhD,Elizabeth R. Bertone-Johnson, ScD,Edward J. Stanek, PhD,Nancy L. Cohen, PhD, RD,Ira S. Ockene, MD
The objective of this investigation is to describe the associations of number of eating episodes and proportion of meals eaten away from home with total serum cholesterol. Data from 499 participants, recruited from a health maintenance organization in cen... see more