11 articles in this issue
Thaer Khoury, MD
Background: Epithelial membrane antigen (EMA) is a glycoprotein, widely used in the differential diagnosis of epithelial neoplasms. Little is known about EMA expression in thymic neoplasms classified based on world health organization (WHO) scheme. ... see more
Frank Chen, MD, PhD,David G. Hicks, MD,Christopher A. D’Angelis, MD, PhD,Haiying Chen, MD,Sheila Sait, PhD,Shaozeng Zhang, MD, PhD
The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase that plays an important role in tumor growth, invasion and metastasis. EGFR Positive immunoreactivity ranged from focal to diffuse in overexpression has been shown in man... see more
Haitao Zhu, PhD, MD,Xianmin Xiao, MD,Shan Zheng, MD,Yiping Shen, PhD,Bai-Lin Wu, PhD
Neuroblastoma is the most frequent pediatric extracranial tumor. It arises from embryonic neural crest cells and exhibits significant heterogeneity of clinical presentation and biologic behavior. Despite the application of aggressive treatments and multip... see more
Haiying Chen, MD,Jianlan Sun, MD, PhD,Lalarukh Aftab, MD,Amy Sands, MD
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, idiopathic and non-neoplastic histiocytic disorder. The most common presentation of RDD is painless cervical lymphadenopathy in a young patient.&... see more
Wei Liu, MD, PhD,Constantine A. Axiotis, MD
Background: Extrauterine adenosarcomata are thought to arise from pre-existing foci of endometriosis. In 1925 Sampson proposed three criteria for a definitive diagnosis of malignancy arising in endometriosis: (1)histological evidence of endometriosi... see more
Merfake H Semret, MD,Sanjeev Sethi, MD,Qi Qian, MD
Introduction Infection is the leading cause of death in patients on chronic immunosuppression. Diagnosis of infection in these patients can be challenging as immunosuppressants can blunt systemic inflammatory response and therefore elude ready detection.
Yiqing Song, MD, ScD,Ka He, MD, ScD
Emerging evidence has suggested favorable effects of marine omega-3 fatty acids on glucose homeostasis, lipid metabolism, endothelial function, and chronic inflammation, which could contribute individually or synergistically to the development of type 2 d... see more
Jiawen Han, MD, PhD
Monoclonal antibodies have emerged as key therapeutic modalities for a range of human diseases. Owing to selective targetting of these agents on tumor cells, cancer has become one of the major focuses for development of monoclonal antibody therapeut... see more
Elena Volozhanina, MD
We were somewhere in the middle of Atlantic Ocean when the captain of the airplane announced: “Is there a doctor on the plane?” I thought to myself: “I don’t like flying, forget doing anything else, there must be at least one more doctor on this plane; I ... see more
Xianwen Shang, MPH,Dong Wang, MD, Msc,Jianping Wang, PhD,Xiaoqi Hu, MD,Songming Du, PhD,Yanping Li, PhD
Background: The prevalence of depressive symptoms among children is rapidly increasing all over the world. The objective of this study was to investigate the prevalence of depressive symptoms and its socioeconomic characteristics among children living in ... see more
Jing Liu, MD, PhD,Jianbo Wan, PhD,Cheng Wei He, PhD
Chemotherapeutic drugs have been conventionally used for the cancer treatments, but the efficacy of the therapy remains problematic. It has been strongly suggested that the anti-inflammatory drugs, such as COX-2 inhibitors, may enhance the anti-cancer eff... see more