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25  Articles
1 of 3 pages  |  10  records  |  more records»
BACKGROUND Factor VIII (FVIII) inhibitors in hemophilia A (HA) patients render FVIII replacement therapy ineffective. Although its development cause is unclear, it has been classified into therapeutic and genetic-related etiologies. Single nucleotide poly... see more

Os pacientes hemofílicos dispõem da tradicional terapia episódica de FVIII, mas, há alguns anos, o conceito de tratamento ganha nova vertente ao aplicá-lo profilaticamente. Além dos benefícios do tratamento profilático com FVIII na redução da frequência d... see more

METHODS: A discrete event (micro-)simulation (DES) model was developed to reproduce every possible HA patient clinical pathway: on-demand (OD) treatment of bleeding, continuous or discontinuous prophylaxis (PRO) with FVIII, inhibitors-tolerance-induction ... see more

The development of a new generation of coagulation factors with improved pharmacokinetic profile will change the paradigm of treatment of persons with hemophilia (PWH). The standard treatment in PWH is represented by regular long-term prophylaxis that, gi... see more

Background Intracranial hemorrhage (ICH) is one of the major bleeding events causing mortality and long-term morbidity in children with hemophilia, especially those who receive on-demand therapy.Objective To evaluate the outcome of children with hemophili... see more

Water, as one of the main sources of life, is an important aspect to public health and safety. Up until now there have been many concerns about water pollution especially in developing countries. Heavy polluted water that is not treated well could cause m... see more

The National Blood Center, Kuala Lumpur interprets laboratory results for the von Willebrand factor (vWF) profile based on guidelines provided by the U.S. National Heart, Lung, and Blood Institute, which were established based on the Caucasian population ... see more


Hemofilia A Adquirida (HAA) é uma desordem hemorrágica incomum causada pelo desenvolvimento de autoanticorpos policlonais da subclasse IgG 4 contra o FVIII. O tratamento usual envolve a administração de FVIII humano ou recombinante parcialmente ativado ev... see more

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