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19  Articles
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Acute myeloid leukaemia (AML) is a clinically heterogeneous haematological cancer with increased incidence in the elderly. Genetic mutations remain important prognostic factors for treatment outcome. Our study determined the prevalence and clinical signif... see more

 
AML t(8;21) harbours the fusion oncoprotein AML1/ETO (AE), a fusion of two transcription factors, AE inhibits proper hematopoietic development as various genes switch are disrupted. FLT3 is a gene crucial for sustenance of leukaemic progression. TERT on t... see more

Acute myeloid leukemia (AML), phenotypically and genotypically is a quite heterogeneous disease. More than 100 cytogenetic aberrations and gene mutations that are specific to this disease are defined (1). A patient who applied to hematology polyclinic of ... see more

Background & Objectives: Molecular genetic abnormalities have a significant role not only in diagnosis but also in determining the clinical course and prognosis. Nucleophosmin-1 (NPM-1) is associated with good prognosis while internal tandem duplication o... see more

The FMS-like tyrosine kinase 3 (FLT3) pathway has an important role in cellular proliferation, survival, and differentiation. Acute myeloid leukemia (AML) patients with mutated FLT3 have a large disease burden at presentation and a dismal prognosis. A num... see more


 
RAS pathway mutations have been linked to paediatric B-cell Precursor Acute Lymphoblastic Leukaemia (BCP-ALL) prognosis, relapse and chemotherapy resistance. Primary chromosomal and gene fusion abnormalities initiate the development of pre- leukaemic clon... see more



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