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16  Articles
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It has been shown that 2-aryl-[1,2,4]triazolo[1,5-c]-quinazolines under the action of nucleophilic agents (hydrazine hydrate, sodium hydroxide, sodium methoxide, hydrochloric acid) undergo hydrolytic cleavage followed by formation of [2-(3-aryl-1H-1,2,4-t... see more

Features of 5-trichloromethyl-2-aryl-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazolines formation as result of [5+1]-cyclocondensation of the corresponding [2-(3-aryl-1H-1,2,4-triazole-5-yl)phenyl]amines with chloral hydrate are described in the article. It h... see more

The present article describes the synthesis of novel spiro-condensed [1,2,4]triazolo[1,5-c]quinazolines. [2-(3-Aryl1H-1,2,4-triazol-5-yl)phenyl]amines were used as effective precursors for the synthesis of the compounds mentioned above. The experimental d... see more

It has been shown that 2-aryl-[1,2,4]triazolo[1,5-c]-quinazolines under the action of nucleophilic agents (hydrazine hydrate, sodium hydroxide, sodium methoxide, hydrochloric acid) undergo hydrolytic cleavage followed by formation of [2-(3-aryl-1H-1,2,4-t... see more

To study the JNK-kinase activity of quinazoline derivatives a series of 4-O-aryl- and 4-N-alkylquinazolines have been synthesized in standard condition of nucleophilic substitution of 4-chloroquinazolines in the presence of potassium carbonate. 4-Chloroqu... see more

The reactions of [5+1]-cyclocondensation of [2-(3-aryl-1H-1,2,4-triazol-5-yl)phenyl]amines with aliphatic and aromatic ketones result in the corresponding 5-R-5-R1-2-aryl-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazolines with good yields. Modi? cation of the... see more

Reactions of [5+1]-cyclocondensation of [2-(3-aryl-1H-1,2,4-triazol-5-yl)phenyl]amines with aliphatic and aromatic aldehydes produce the corresponding 5-R-2-aryl-5,6-dihydro- or 5-R-2-aryl-[1,2,4]triazolo[1,5-?]quinazolines depending on the cond... see more

In the present paper, 50 new derivatives 2-[8-R1-9-R2-10-R3-3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetic acids have been described. It was shown that alkylation of potassium 8-R1-9-R2-10-R3-3-R-2-oxo-2H-[1,2,4]triazino­[2,3-c]quinazolin... see more

Import-substitution of medicines, in particular antitumor activity, is an important component of the strategy for medical industry development, and among other, provides for the scientific research activation aimed at the creation of innovative medicines.

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