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17  Articles
1 of 3 pages  |  10  records  |  more records»
A scalable, cost-efficient and simple synthetic pathway towards pot­ential bivalent opioid/dopamine receptor ligands was developed and optimized. Three novel compounds that contain both opioid and dopamine pharmaco­phores linked by the four methylene grou... see more

The discovery of new chemotherapeutics with novel bioactivities and functionalities to fight current emerging diseases has become the most significant research in pharmaceutical science. Schiff bases are versatile pharmacophores that can form complexes by... see more

Functionalization of heterocyclic systems with sulfur- and phosphorus-containing pharmacophores has long shown itself as an effective method for construction of new bioactive substances. At the same time, some types of the compounds are represented by onl... see more

The reactivity of substituted 5,7-dichloro-9-hydrazine acridine that exhibit various pharmacological activity by studying acid-base equilibria in the ethanol-water binary solvent (50 mol % ethanol) at 250? using the method of potentiometric titration has ... see more

Aim. To study the acid-base properties of derivatives of 2-(benzoylamino)(1-R-2-oxoindolin-3-ylidene)acetic acid substituted by the location 1 of oxoindolin fragment.Results and discussion. The compounds studied are weak acids, their strength decreases wi... see more

The results of the study of N,N?-(ethane-1,2-dyyil)bis(quinoline-2-carboxamide) as a potential hypoglycemic agent on the model of alloxan diabetes, as well as in normoglycemic rats are presented, the “dose – effect” relationship and acute toxicity in vari... see more

Searching biologically active compounds has been one of the major duties of organic chemists. We previously constructed a library of synthetic 12-arylbenzoacridines and found estrogenic and anti-estrogenic agents. With taking the shot-gun approach into co... see more

Herein, the synthesis and pharmacological evaluation of 13 novel compounds, designed as potential heterobivalent ligands for m-opioid receptor (MOR) and dopamine D2 receptors (D2DAR), are reported. The compounds consisted of anilido piperidine and N-... see more

The reactivity of substituted 5,7-dichloro-9-hydrazine acridine that exhibit various pharmacological activity by studying acid-base equilibria in the ethanol-water binary solvent (50 mol % ethanol) at 250? using the method of potentiometric titration has ... see more

1 of 3 pages  |  10  records  |  more records»