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10  Articles
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The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. The present investigation is an attempt to improve the solubility and dissolution rate of diacerein (a poorl... see more

Diacerein, anti-inflammatory drug used in the treatment of osteoarthritis. Being a BCS class II drug, it has poor solubility, dissolution rate and other physicochemical properties. Thus the aim of present study was to prepare co-crystals of diacerein to i... see more

Aim. To assess the levels of markers of the bone synthesis and system inflammation in patients with osteoarthritis (OA) in combination with obesity and their dynamic under the influence of basic treatment.Materials and methods. The research included 40 wo... see more

Aim. To assess the levels of markers of the bone synthesis and system inflammation in patients with osteoarthritis (OA) in combination with obesity and their dynamic under the influence of basic treatment.Materials and methods. The research included 40 wo... see more

Background: Infl ammation is an important mechanism in the pathogenesis of osteoarthritis (OA). Proinfl ammatory mediators, especially interleukin-1ß (IL-1ß), play a signifi cant role in the occurrence of joint infl ammation, which lead to pain and limita... see more

Disease Modifying Osteoarthritis Drugs (DMOADs) merupakan agen yang dapat mencegah, menghambat perkembangan atau mengembalikan perubahan morfologi pada penderita osteoarthritis. Salah satu yang termasuk DMOADs ini adalah diacerein. Diacerein menstimulasi ... see more

Introduction : Osteoarthritis is a major cause of disability and is among the most frequent forms of musculoskeletal disorders. The goal of pharmacological treatment is usually to control symptoms of the disease, pain, and limitation of function, which is... see more


Osteoarthritis (OA) is characterized by degradation of joint cartilage which produces severe pain and swelling leading to immobility of the joint. OA can affect people of all age, gender and geographical locations, and the cost associated with long term m... see more

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