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21.074  Articles
1 of 2.108 pages  |  10  records  |  more records»
The role of interleukins (ILs) and oxidative stress (OS) in precipitating neurodegenerative diseases including sporadic Alzheimer’s disease (AD), requires further clarification. In addition to neuropathological hallmarks—extracellular neuritic amyloid-ß (... see more

Innate and adaptive immune cells from myeloid and lymphoid lineages resolve host infection or cell stress by mounting an appropriate and durable immune response. Upon sensing of cellular insults, immune cells become activated and undergo rapid and efficie... see more

Metabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cardiovascular diseases. Interestingly, despite the fact... see more

We have previously shown that exposure to high dose ascorbate causes double stranded breaks (DSBs) and a build-up in S-phase in glioblastoma (GBM) cell lines. Here we investigated whether or not this was due to genotoxic stress as well as metabolic stress... see more

The ability of protein to reversibly bind with membrane components is considered to be one of the oldest mechanisms of cell response to external stimuli. Erythrocytes have a well-developed mechanism of an adaptive response involving sorption-desorption pr... see more

Background: Abdominal adiposity has been linked to metabolic abnormalities, including dyslipidemia, oxidative stress, and low-grade inflammation.Objective: To test the hypothesis that consumption of 100% orange juice (OJ) would improve metabolic, oxidativ... see more

Background: A high percentage of patients admitted to the Intensive Care Unit (ICU) have Systemic Inflammatory Response Syndrome (SIRS) criteria. Free radicals play an important role in initiation and development of SIRS. The purpose of this study was to ... see more

Background: A high percentage of patients admitted to the Intensive Care Unit (ICU) have Systemic Inflammatory Response Syndrome (SIRS) criteria. Free radicals play an important role in initiation and development of SIRS. The purpose of this study was to ... see more

Mitochondrial dysfunction and oxidative stress have been implicated in the pathogenesis of a number of diseases and conditions. Oxidative stress occurs once the antioxidant defenses of the body become overwhelmed and are no longer able to detoxify reactiv... see more

1 of 2.108 pages  |  10  records  |  more records»