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1.992.120  Articles
1 of 199.212 pages  |  10  records  |  more records»
The peculiarities of the reaction between 3-(2-aminophenyl)-6-R-1,2,4-triazin-5(2H)-ones and cyclic anhydrides of non-symmetric (2-methylsuccinic, 2-phenylsuccinic and camphoric) acids have been described in the present article. The influence of electroni... see more

The search for new groups of anti-inflammatory and analgesic drugs is a topical issue of the current medicinal chemistry. It is caused by numerous diseases that are accompanied by pain and inflammation, as well as by imperfection of the existing drugs aim... see more

Water mediated one-pot, four-component synthesis of substituted 2H-indazolo[2,1-b]phthalazine-triones from dimethyl phthalate, hydrazine, dimedone and aromatic aldehydes have been reported in the presence of p-toluenesulfonic acid (PTSA) as catalyst at 10... see more

Multicomponent domino reactions are an effective modern approach in the synthesis of different types of organic compounds, including biologically active pyrans.Aim. To study the three-component interaction of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide with di... see more

Reaction of Schiff bases with thioglycolic acid was set up with Dean stark apparatus in toluene. The Schiff bases containing aniline derivatives 1a and 2a gave thiazolidin-4-one containing compounds 1b and 2b only; 1-naphthyl amine gave a mixture of thiaz... see more

Domino-type Knoevenagel-Michael-hetero-Thorpe-Ziegler and Knoevenagel-hetero-Diels-Alder interactions using 1-ethyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide and aliphatic aldehydes as initial compounds have been studied. These reactions have led to 2-ami... see more

The intensive and purposeful search of fundamentally new diuretics conducted by our research laboratory among the derivatives of 4-hydroxyquinolin-2-ones has found 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij] quinoline-6-carboxylic acid 2-carboxyani... see more

Malaria is a parasitic disease caused by various species of the Plasmodium parasite. In 2016, there were about 216 million cases resulting in 445,000 deaths, with sub-saharan Africa bearing the heaviest burden of the disease. The currently recommended tre... see more

Currently, antibiotic resistance is becoming a tremendous threat in treatment of bacterial and fungal infections. Therefore, a topical question is the search of new classes of antimicrobial drugs. The present article is devoted to the study of antimicrobi... see more

1 of 199.212 pages  |  10  records  |  more records»