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541.566  Articles
1 of 54.158 pages  |  10  records  |  more records»
Glycogen synthase kinase-3? (GSK-3?) is an important class of therapeutic drug target currently receiving wide attention. In our computational approach, shape-based similarity search was used to screen the SPECS database, based on the shape of Tideglusib ... see more

Background. High cholesterol can lead to cardiovascular disease. Hoarding and accumulation of cholesterol in the blood will cause stiffness in arteries and trigger the formation of atherosclerotic lesions. Estrogen has a role as an antioxidant that can pr... see more

Sucrose-phosphate synthase (SPS) is a key enzyme catalyzing the formation of sucrose-6-phosphate through the transfer of uridine-diphosphate glucose (UDP-G) as a donor to fructose-6-phosphate (F6P) as an acceptor. Plant SPS consists of three main domains:... see more

Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disease that easily induces hepatitis, cirrhosis, and even liver cancer. The long-term use of NAFLD therapeutic drugs produces toxicity and drug resistance. Therefore, it is ... see more

There were studied the changes of content of NO-synthase and metabolism products of nitrogen oxide in experimental hepatitis during treatment with inhibitors of its synthesis. According to the results of our research, the use of non-selective inhibitor L-... see more

Introduction. Nitrogen (II) oxide (NO) is a highly reactive molecule involved in the regulation of numerous biochemical processes and physiological functions. The role of NO/NO-synthase of spermatozoa in the NO/NOS system of sperm cells in male infertilit... see more

Resveratrol is a potent anticancer agent resulted as the main product of enzymatic reaction between common precursor in plants and Stilbene Synthase enzyme, which is expressed by sts gene. Characterization of internal fragment of Stilbene Synthase (STS) e... see more

The quality of wheat grains is often negatively affected by pre-harvest sprouting (PHS), a complex trait with a poorly understood genetic background. In this study two wheat cultivars differing in their susceptibility to PHS were used to investigate expre... see more

Purpose: inflammatory processes investigation in the rhegmatogenous retinal detachment pathogenesis and analysis of correction methods effectiveness.On the 7th day in experimental groups observed increase in the interleukin 1ß level and inducible NOS acti... see more

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