ARTICLE
TITLE

Synthesis, characterization and pharmacological evaluation of some new 6(2-Chloro 3,5-substituted phenyl)-1,2,4-triazine derivatives

SUMMARY

6(2-Chloro 3,5-substituted phenyl)-1,2,4-triazine derivatives were synthesized and studied for evaluation of anticonvulsant activity by maximal electroshock test and neurotoxicity by rotarod motor test. Some compounds were displayed protection against induced seizures at a dose level 100 mg/kg after 0.5 and 4.0 h and while some compounds were displayed neurotoxicity at highest administered dose (300 mg/kg) after 4.0 h. Screening data revealed that one compound was found most active in series with little CNS depressant effect without neurotoxicity when compared to standard drugs Phenytoin and Carbamazepine.

PAGES
pp. 181 - 188

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