SUMMARY
Volkovoy V. A., Sevrukov ?. V., Fomina G. P., Karabut L. V., Lukjanova L. V. ???????? ????????? ?????? ??????????????? ?????????? ???????? 5,7-???????-1?-?????? [2,3-d] ????????? ?? ?????? ???????? ??????????????????? ???????? = Investigation primery assessment antioxidant action derivatives 5,7-dyhydro-1?-pyrolo [2,3-d] pyrymidin in model of acute tetrachlormetan hepatitis. Journal of Education, Health and Sport. 2015;5(7):429-438. ISSN 2391-8306. DOI 10.5281/zenodo.20543http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%287%29%3A429-438https://pbn.nauka.gov.pl/works/587930http://dx.doi.org/10.5281/zenodo.20543Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartosc merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacja MNiSW z dnia 2 czerwca 2014 r., ze w roku 2014 nie bedzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 20.06.2015. Revised 15.07.2015. Accepted: 15.07.2015. UDC 615.275.4:547.822.7:616.36-002:616.127??? 615.275.4:547.822.7:616.36-002:616.127 ???????? ????????? ?????? ??????????????? ?????????? ???????? 5,7-???????-1?-?????? [2,3-d] ????????? ?? ?????? ???????? ??????????????????? ????????Investigation primery assessment antioxidant action derivatives 5,7-dyhydro-1?-pyrolo [2,3-d] pyrymidin in model of acute tetrachlormetan hepatitis ?. ?. ????????, ?. ?. ????????, ?. ?. ??????, ?. ?. ???????, ?. ?. ???’????? V. A. Volkovoy, ?. V. Sevrukov, G. P. Fomina, L. V. Karabut, L. V. Lukjanova ???????????? ?????????????? ???????????, ??????, ??????? National University of Pharmacy, Kharkiv, Ukraine AbstractThe research results of the antioxidant properties of 15 compaunds, derivatives 5,7-dyhydro-1?-pyrolo [2,3-d] pyrymidin. It has been determined that 12 of them act as antioxidants on the model of acute hepatitis caused by tetrachlormethane. They have positive effect upon the general condition of the animals (probability of survival), state of antioxidant system (AS) and the process of lipid peroxidation (LPO). The most active are the substances of KMS-190, KMS-191, KMS-211, KMS-214, KMS-217 because they do not just decrease the reactants content of thiobarbituric acid (TBA), and increase the level of reduced glutathione (GSN) regarding to control pathology and substance of comparison – mexidol, but also affect positively on the indexes of liver mass coefficient (LMC).Keywords: lipid peroxidation, antioxidant activity, hepatitis, tetrachlormetane, derivatives 5,7-dyhydro-1?-pyrolo [2,3-d] pyrymidin. ???????? ?????? ???????? ?????????? ?????????? ??????????????? ???????????? 15 ??????-???????? 5,7-???????-1?-??????[2,3-d] ?????????. ???????????, ?? ?? ?????? ???????? ????????, ??????????? ??????????????? 12 ? ??? ?????????? ?????????????? ??????????. ???? ???????????????? ?????????? ??????? ?? ????????? ???? ?????? (???????????), ???? ??????????????? ??????? ?? ?????? ??????????? ????????? ???????. ?????????????? ? ???????? ??? ?????? KMS-190, KMS-191, KMS-211, KMS-214, KMS-217, ???????? ???? ?? ?????? ???????? ????? ?????????? ??????????????? ??????? (???) ? ?????????? ?????? ???????????? ?????????? ???????? ??????????? ????????? ?? ????????? ?????????? – ?????????, ??? ? ????????? ????????? ?? ????????? ???????? ??????????? ???????.??????? ?????: ????????? ????????? ???????, ?????????????? ??????????, ???????, ??????????????, ??????? 5,7-???????-1?-??????[2,3-d] ?????????. ??????????????? ????????? ?????? ??????????????? ?????????? ??????????? 5,7-???????-1?-?????? [2,3-d] ????????? ?? ?????? ??????? ??????????????????? ????????. ? ?????? ????????? ?????????? ???????????? ??????????????? ??????? 15 ?????????? – ??????????? 5,7-???????-1?-???????[2,3-d]?????????. ???????????, ??? ?? ?????? ??????? ????????, ?????????? ????????????????, 12 ?? ??? ????????? ??????????????? ??????????. ??? ??????????????? ????????????? ???????? ?? ????? ????????? ???????? (????????????), ????????? ??????????????? ??????? (???) ? ??????? ??????????? ????????? ??????? (???). ???????? ????????? ???????? ???????? ??? ??????? KMS-190, KMS-191, KMS-211, KMS-214, KMS-217, ????????? ??? ?? ?????? ??????? ?????????? ?????????? ??????????????? ??????? (???) ? ???????? ??????? ??????????????? ?????????? (GSH) ???????????? ??????????? ????????? ? ????????? ????????? – ?????????, ?? ? ???????????? ?????? ?? ?????????? ????????? ??????????? ?????? (???).???????? ?????: ?????????? ????????? ???????, ??????????????? ??????????, ???????, ??????????????, ??????????? 5,7-???????-1?-???????[2,3-d] ?????????.