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1.036.713  Articles
1 of 103.672 pages  |  10  records  |  more records»
Aim. To study the antihypoxic and antioxidant activity of 5,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidine derivatives on the models of the experimental pathology.Materials and methods. The study of the antihypoxic activity of 5,7-dihydro-1H-pyrrolo-[2,3-d]pyrimi... see more

Aim. To study the antihypoxic and antioxidant activity of 5,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidine derivatives on the models of the experimental pathology.Materials and methods. The study of the antihypoxic activity of 5,7-dihydro-1H-pyrrolo-[2,3-d]pyrimi... see more

The study is devoted to the rational search of modern potential antimicrobial agents among of 4-thiazolidine(thi)ones. 5-R,R’-Enamin(thi)ones of thiazolidinone series have been tested for design and the initial screening of the antibacterial properties. T... see more

The synthesis of new N, N`-disubtituted 5-spiro-2,4,6-trihydropyrimidinetriones by ring-closing metathesis reactions has been presented in this work. Starting compounds for obtaining of spirocycles (5,5-diallyl-1,1-dioxythiolanyl-2,4,6-trihydropyrimidinet... see more

Development of resistance of yeast-like fungi belonging to the Candida genus to the existing antifungal medicines as well as the high toxicity and low tolerance of these medicines in many cases stipulate the acute need for new antibiotic compounds. In thi... see more

It has been experimentally proven that with the intraperitoneal way of introduction of Dezapur the maximum tolerated dose for mice is 2000 mg/kg, the least toxic dose – 1000 mg/kg, the median lethal dose – 3000 mg/kg. When the dose of 3500 mg/kg was intro... see more

The reactivity of substituted 5,7-dichloro-9-hydrazine acridine that exhibit various pharmacological activity by studying acid-base equilibria in the ethanol-water binary solvent (50 mol % ethanol) at 250? using the method of potentiometric titration has ... see more

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