SUMMARY
Hyperlipidemia is linked to an elevated risk of atherosclerosis disease and managing this risk factor is crucial. This study was aimed at investigation of high performance liquid chromatographic (HPLC) analysis and antihyperlipidemic effect of hydroalcoholic extract of seeds of the plant Cucumis sativus L in Wistar albino rats. The rats were divided into groups A, B, C and D. All the groups except group A were administered with diet having high cholesterol and given intraperitoneal injection of Triton X-100 to induce hyperlipidaemia. Group A served as normal. Group B served as hyperlipidemic control. Group C (standard) and D (plant treated) were administered with simvastatin (10 mg/kg) and hydroalcoholic extract of the plant (400 mg/kg) respectively daily for 7 days after one week of inducing hyperlipidemia. The biochemical parameters of all the groups were estimated after one week of administration of plant extract using kits of Roche Cobas C111 chemistry analyzer. Histological studies of liver and heart tissues were also done. HPLC study showed the presence of compounds in the extract. The plant decreased the levels of total cholesterol, triglycerides, alanine aminotransferase, low and very low-density lipoprotein cholesterol significantly. The plant may be used as dietary supplement in combating hyperlipidemia.