SUMMARY
In most modern symmetric ciphers, substitution boxes are non-linear core components that provide robust security and confusion. The construction of active S-boxes has been hot object among safely experts. The goal is at build a cryptographically active S-box, number of researchers have built an S-Box using RNA, DNA, chaotic systems, etc. In this article, we used new approach to generate multiple S-Boxes based on the Permutation of Last Layer algorithms (PLL) to replacement the place (permutation) of the pieces generated from the Magic Cube and instead of using static S-Boxes, we can generate dynamic S-Boxes to use various S-Boxes in every round to add to confusion. When comparing the proposed algorithm with other searches and tests on it. We found it has achieved a high percentage of success comparable to the S-Box from chaotic and etc. The proposed design passes S-Box test criteria effectively, these tests: invertibility, completeness, avalanche, strict avalanche, and balanced are among S-Box test criteria. The results of the analysis show that the novel S-Box overrun each of these statistical tests, has a good avalanche impact, and thus can protect against a wide range of attacks. Because S-Box and its reverse take but smaller milliseconds to construct it ability be applied in a variety of lightweight applications