ARTICLE
TITLE

Hemostasis disturbances in patients with acute pancreatitis and the ways of its correction

SUMMARY

The literature review imposed the experimental and clinical data on the changes in the hemostatic systemat acute pancreatitis. The reasons of hemostatic disorders and possible ways of its correction were identified.Disturbance in the coagulation is a feature at acute pancreatitis and is associated with disease severity. Theresults of experimental studies in animals and clinical studies suggest that modulation of hemostasis can provide atherapeutic target for the treatment of this disease. Inhibition of the coagulation cascade can prevent intravascularcoagulation and inflammation in the pancreas and distant organs, thereby preventing systemic complications inpatients with acute pancreatitis.

PAGES

 Articles related

I. Ya. Dziubanovskyi, B. M. Verveha, S. R. Pidruchna, N. A. Melnyk, S. I. Yavorska    

Introduction. In acute peritonitis, any surgical intervention leads to impaired immune protection with the development of postoperative purulent-septic complications, which increases several times the likelihood of death, especially in persons with secon... see more


R. V. Verba, I. M. Klishch    

To study the influence of hypothyroidism on the course of free-radical processes and state of antioxidant system in rats with acute extensive peritonitis, the production of active forms of oxygen by mononuclear leukocytes, concentration of lipid hydroper... see more


I. Ya. Dzyubanovsky, B. M. Verveha, S. R. Pidruchna, N. A. Melnyk, A. A. Hudyma    

Introduction. The accumulation of oxidized proteins is considered as one of the factors regulating the synthesis and degradation of proteins, the activation of multicatalytic proteases, which selectively destroy oxidized proteins. It is known that diabet... see more


V. I. Bondarchuk    

Introduction. To date, it is proved that the leading factor in the development and progression of various diseases is not the source that caused the pathological condition, but violations caused by altered, strengthened or vice versa, weakened immune pro... see more


I. Ya. Dziubanovskyi, B. M. Verveha, S. R. Pidruchna, N. A. Melnyk    

Summary. Acute peritonitis increasingly leads to the development of severe postoperative complications, the percentage of fatal cases increases. Diabetes mellitus continues to be one of the urgent problems of medicine, because it is one of the most commo... see more