SUMMARY
The integrated ABC/VEN/frequency analysis was used to conduct the clinical and economic analysis of pharmacotherapy of patients with toxic hepatitis (TH) in the Kharkiv hospital. It has been found that pharmacotherapy in the Gastroenterology department in the Kharkiv hospital did not always comply with the clinical protocol of TH treatment because only 15% of patients received all four essential types of pharmacotherapy recommended by the clinical protocol (detoxication therapy, medicines for normalization of the gastrointestinal tract, hepatotropic drugs and vitamins), and 85% of patients were treated with 1-3 drugs for TH. Most drugs (4-7) were prescribed to patients for treating comorbidities, indicating polypharmacy in pharmacotherapy of patients with the primary diagnosis “toxic hepatitis”. Comparison of the results of the integrated ABC/VEN/frequency analysis indicates that the main funds in the Kharkiv hospital were spent on vitally necessary medicines that were a greater proportion of prescriptions. However, TH pharmacotherapy in this healthcare institution did not always comply with the normative documents since a significant portion of funds from 7.85% to 22.13% was spent on drugs missing in the clinical protocols for treating TH and comorbidities, as well as in the National Drug Formulary of Ukraine (the 5th edition). Therefore, it is possible to optimize the costs by reducing prescriptions of minor drugs and administering those drugs that are included in the clinical protocol of TH treatment.