ARTICLE
TITLE

The influence of ademetionine on the state of prooxidantantioxidant balance in rats with glycerol-induced acute kidney failure

SUMMARY

The influence of ademetionine (heptral) on the state of prooxidant-antioxidant balance in rats’ kidneys andblood under the conditions of glycerol (rhabdomyolytic) acute renal failure was studied in the experiment. It isestablished, that intraperitoneal ademetionine injection in the dose of 20 mg/kg of the body weight normalizes theprooxidant-antioxidant balance indices, which manifested by a decrease of lipid and protein peroxidation intensity,increase catalase and glutathione peroxidase activity ?nd increase of the ceruloplasmin level down to the indicesof the control animals.

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