ARTICLE
TITLE

Development of the methodology for the estimation of enalapril maleate in medicines

SUMMARY

Introduction. Thin layer chromatography, or TLC, is a method for analyzing mixtures by separating the compounds in the mixture. TLC can be used to help determine the number of components in a mixture, the identity of compounds, and the purity of a compound.The aim of the study – to develop a thin layer chromatography method for the estimation enalapril in medicines.Research methods. The present study is assessed system solvents of enalapril maleate for thin layer chromatography.Results and Discussion. Method of identification of enalapril maleate in medicines by TLC was developed. We established that the most optimal Rf observed using mobile phase: ammonia (25 %) – propanol (30:70). The detection limits of enalapril maleate in this system are 0.2 mcg. However, those mobile phase is the most express. We explored the validation characteristics – specificity and suitability of the chromatographic system that met, the eligibility criteria established by the SPU.Conclusions. We developed chromatographic methods of identification of enalapril maleate in medicines. The proposed method is rapid, economical and simple.

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