13 articles in this issue
Anna Meiliana,Nurrani Mustika Dewi,Andi Wijaya
BACKGROUND: Aging tissues lose their homeostatic and regenerative capacities, which has been linked to the degeneration of the stem cells such as the tissue-specific stem cells, the stem cell niches, and systemic cues that regulate stem cell activity.CONT... see more
Pudji Rahaju,Ayunita Tri Wirattami,Ferry Sandra,Steffi Kurniawan,Khairun Nisa,Soehartono Soehartono,Edi Handoko,Ahmad Dian Wahyudiono,Hendradi Surjotomo,Hendy Setyo Yudhanto,Nanik Setjowati
BACKGROUND: Progression of laryngeal carcinoma can be classified with the clinical staging, however there are different patterns of progressions observed in the patient with the same clinical stage which also affects their prognoses. Therefore biomarkers ... see more
Yalista Fatia Nadia,Resda Akhra Syahrani,Sekar Arumsari,Mohamad Sadikin,Septelia Inawati Wanandi
BACKGROUND: Cancer stem cells (CSCs) is defined as tumor initiating cells within tumor that maintain stemness properties and tumorigenicity. Extracellular pH of CSCs in in vitro condition is important for supporting cell proliferation which may also regul... see more
Nur Ainina Abdollah,Nabil Izzatie Mohamad Safiai,Muhammad Khairi Ahmad,Kumitaa Theva Das,Siti Razila Abdul Razak
BACKGROUND: Molecular alterations of microRNA130a (miR130a) are observed in many types of cancers, including non-small cell lung cancer (NSCLC). However, the role of miR130a in NSCLC has been poorly studied.METHODS: In this study, clustered regularly inte... see more
Nuni Sulastri,Bachti Alisjahbana,Resvi Livia,Edhyana Sahiratmadja
BACKGROUND: Neutrophils and lymphocytes play a significant role in inflammation and a high ratio of neutrophils over lymphocytes (NLR) has been used as an inflammatory marker to predict the severity of various diseases. Here we compared the NLR among pulm... see more
Nurul Syuhada Nordin,Yong Yoke Keong,Siti Farah Md Tohid,Zetty Nadia Md Zain,Muhammad Nazrul Hakim
BACKGROUND: Eventhough 6-Mercaptopurine act as a major drug for rheumatoid arthritis (RA) treatment, however, its toxicity become a limitation. Therefore, this current study investigated whether 6-hydroxy-2-mercaptopurine (6H2MP) and 6-thioguanine (6TG) c... see more
I Gede Widhiantara,Anak Agung Ayu Putri Permatasari,I Wayan Rosiana,Putu Angga Wiradana,Luh Putu Widiastini,I Made Jawi
BACKGROUND: The discovery of herbal ingredients for antihypercholesterolemic and to improve male reproductive function is very necessary due to high-cholesterol diet factors. Blumea balsamifera leaf extract (BBLE) is known to be able to increase the numbe... see more
Hamsu Kadriyan,Eka Sunarwidhi Prasedya,Nova Audrey Luetta Pieter,Masyita Gaffar,Amsyar Akil,Agusalim Bukhari,Budu Budu,Andi Alfian Zainuddin,Rina Masadah,Achmad Chusnu Romdhoni,Abdul Qadar Punagi
BACKGROUND: Nasopharyngeal cancer (NPC) is known to release a specific exosome. NPC-derived exosome (NPC-Exo) could carry p53. However, information regarding the type of p53 carrier on NPC-Exo remains limited. This study aims to introduce our important fi... see more
Mieke Actress Hanna Nelly Kembuan,Arthur Hendrik Philips Mawuntu,Yohanna Yohanna,Feliana Feliana,Melke Joanne Tumboimbela
BACKGROUND: The Coronavirus disease 2019 (COVID-19) pandemic has forced the health workforce to take mitigative measures such as physical distancing, screening, personal protective equipment donning, and confinement on patient care. We aimed to study the ... see more
Dina Keumala Sari,Ridha Dharmajaya,Mutiara Indah Sari,Dewi Masyithah Darlan
BACKGROUND: The presence of vitamin D receptor (VDR) polymorphism and high levels of inflammatory markers are predisposing factors indicating disease progression and malnutrition. To meet nutritional needs in maintaining nutritional status in tuberculosis... see more
Theresia Ilyan,Dwi Retnoningrum,Meita Hendrianingtyas,Dian Widyaningrum,Banundari Rachmawati
BACKGROUND: Serum levels of 25-hydroxyvitamin D (25(OH)D), prostaglandin E2 (PGE2), and cyclooxygenase 2 (COX2) expression differ between breast cancer stages. Since, previous studies showed mixed results, in this study, we aimed to analyze vitamin D leve... see more
Ferry Sandra,Jennifer Putri,Hilary Limen,Blanca Sarizta
BACKGROUND: The potential of the caffeic acid in other important Receptor Activator Nuclear Factor kB Ligand (RANKL)-Tumor Necrosis Factor (TNF)a-induced osteoclastogenic signaling pathways has not been known. Therefore, the current study was conducted to... see more
Dina Keumala Sari,Liza Meutia Sari,Lidya Imelda Laksmi,Farhat Farhat,Elvita Rahmi Daulay,Ferry Sandra,Zulfikar Lubis,Ratna Akbari Ganie
BACKGROUND: Saliva has been suggested as a substitute of serum for the detection of 25 Dihydroxyvitamin D (25(OH)D) in healthy people. However, investigation of salivary 1,25(OH)D has not been clearly reported. Vitamin plays important roles in inhibiting ... see more