ARTICLE
TITLE

A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion

SUMMARY

Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 ?m) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. 

PAGES
pp. S136 - S143

 Articles related

Kelly A. Patyk, Mary J. McCool-Eye, David D. South, Christopher L. Burdett, Susan A. Maroney, Andrew Fox, Grace Kuiper, Sheryl Magzamen    

Comprehensive and spatially accurate poultry population demographic data do not currently exist in the United States; however, these data are critically needed to adequately prepare for, and efficiently respond to and manage disease outbreaks. In respons... see more


Hemanth Kumar Ambala    

This paper introduces a novel approach to integrate IOT with an intelligent Industrial Load Management System. A virtual control system is designed to balance the supply of electricity on the network with the electrical load of an industry by recovering ... see more


Amy Singer    

This article discusses the complexity of literary analysis and the implications of using fiction as a source of sociological data. This project infuses literary analysis with sociological imagination. Using a random sample of children’s novels published ... see more


Edirisingha Arachchige Gamini Fonseka    

According to the theory of dialogism propounded by Mikhail Bakhtin, all discourse in the novel is a product of a process of dialogic imagination. Yet heteroglossic situation in the novel differs from general narration, as it involves interaction among tw... see more


Wenjing Zhang, Neng Huang, Jiantao Zheng, Xingyu Liao, Jianxin Wang and Hong-Dong Li    

The advent of third-generation sequencing (TGS) technologies, such as the Pacific Biosciences (PacBio) and Oxford Nanopore machines, provides new possibilities for contig assembly, scaffolding, and high-performance computing in bioinformatics due to its ... see more

Revista: Genes