SUMMARY
Bagmut I. Yu., Popova T. M., Titkova A. V., Philipchenko S. M., Shepylieva N. V. The influence of sub-toxic dose xenobiotic on immune response of experimental animals = ????? ???????????? ??? ????????????? ?? ?????? ????????? ? ????????????????? ?????? = ??????? ?????????????? ??? ????????????? ?? ???????? ????? ? ????????????????? ????????. Journal of Education, Health and Sport. 2016;6(11):629-639. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.200862http://ojs.ukw.edu.pl/index.php/johs/article/view/4066 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016. UDK 613.6.027: 663.97.05 THE INFLUENCE OF SUB-TOXIC DOSE XENOBIOTIC ON IMMUNE RESPONSE OF EXPERIMENTAL ANIMALS I. Yu. Bagmut, T. M. Popova, A. V. Titkova, S. M. Philipchenko, N. V. Shepylieva Kharkiv Medical Academy of Postgraduate Education SummaryThe polyester is widely used in all sectors of the economy. The polyester influence on the cellular and humoral immunity has been required an integrated research. The actual medical-biological problem is immune deficiency indicators and they need to substantiate during immune toxicological research. One of the scientific directions is the investigation of polyols influence on immunobiological resistance of the human organism. The results can be used for developing of methods to increase the non-specific reactivity.This study examines mechanisms of cellular and humoral immunity disorders of mice and rats after prolonged oral administration of Laprol- 604. Oral consumption of Laprol-604 has been shown to result in inhibition of cellular and humoral immunity of laboratory animals. The study has been performed as part of the research topic of Kharkiv Medical Academy of Postgraduate Education «Cellular-molecular mechanisms of inflammation associated with chronic diseases», the state registration number 015U001186.Keywords: polyester, Laprol-604, humoral immunity, cellular immunity, spleen, lymph nodes. ????? ???????????? ??? ????????????? ?? ?????? ????????? ? ????????????????? ?????? ?. ?. ??????, ?. ?. ??????, ?. ?. ???????, ?. ?. ??????????, ?. ?. ???????? ?????????? ??????? ???????? ?????????????? ?????? ??????????????? ?????? ???????????????? ? ???? ???????? ?????????. ????? ?????????? ?? ??????????? ?????????? ?? ???????????? ???????? ??????? ???????????? ???????????. ???????? ??????-??????????? ????????? ? ????????? ?????????????, ?? ? ???? ??????? ??? ??????? ??????????????? ????????????. ????? ? ???????? ????????? ? ???????? ?????? ???????? ?? ??????????????? ?????????????? ????????? ??????. ???????? ?????????? ?????? ???? ??????????? ??? ???????? ??????? ?????????? ????????????? ????????????.? ????? ?????? ????????????? ????????? ???????? ?????????? ? ???????????? ????????? ? ????? ? ????? ????? ????????? ???????????? ???????? ???????-604. ????????, ?? ?????????? ???????? ???????-604 ?????????? ?? ??????????? ?????????? ? ???????????? ????????? ? ??????. ??????????? ???? ????????? ? ?????? ???????-????????? ???? ??????????? ???????? ???????? ?????????????? ?????? «????????-??????????? ????????? ?????????, ???'????? ? ?????????? ??????????????» (????? ????????? ?????????? 015U001186).??????? ?????: ?????????, ??????-604, ??????????? ????????, ????????? ????????, ?????????, ?????????? ?????. ??????? ?????????????? ??? ????????????? ?? ???????? ????? ? ????????????????? ???????? ?. ?. ??????, ?. ?. ??????, ?. ?. ???????, ?. ?. ??????????, ?. ?. ???????? ??????????? ??????????? ???????? ??????????????? ??????????? ??????????????? ?????? ???????????? ?? ???? ???????? ?????????. ??????? ?????????? ?? ???????????? ?????????? ? ???????????? ????????? ??????? ???????????? ????????????. ?????? ??????-????????????? ????????? ???????? ?????????? ??????????????, ??? ? ???? ??????? ??? ???????? ????????????????? ?????????????. ????? ?? ??????? ??????????? ???????? ???????? ??????? ???????? ?? ??????????????????? ?????????????? ????????? ????????. ?????????? ?????????? ????? ???? ???????????? ??? ?????????? ??????? ????????? ??????????????? ????????????.? ????????? ?????? ??????????????? ????????? ????????? ?????????? ? ???????????? ?????????? ? ????? ? ???? ????? ??????????? ???????????? ???????? ???????-604. ????????, ??? ??????????? ???????? ???????-604 ???????? ? ????????? ?????????? ? ???????????? ?????????? ? ????????. ???????????? ???? ????????? ? ?????? ??????-????????????????? ???? ??????????? ??????????? ???????? ??????????????? ??????????? «????????-???????????? ????????? ??????????, ????????? ? ???????????? ?????????????» (????? ??????????????? ??????????? 015U001186).???????? ?????: ?????????, ??????-604, ??????????? ?????????, ????????? ?????????, ?????????, ????????????? ????.