SUMMARY
While developing, preparing, packing, storing and using medicines the measures should be taken to ensure their microbiological purity taking into account the requirements of the general pharmacopoeial article “Microbiological purity of medicines”. In order to prevent microbial contamination of products it is necessary to provide them with the effective preservative action due to the introduction of antimicrobial preservatives or due to the antimicrobial preservative action of active substances and appropriate conditions of production. The aim of the work is to study the effectiveness of the preservative action of the ointment and rectal suppositories with liquorice root extract in accordance with the general pharmacopoeial article “Efficiency of antimicrobial preservatives”. The criterion for evaluating the efficiency of the preservative action of the samples investigated is reduction of the number of viable cells of microorganisms in the medicines for a certain period of time after their contamination. During the experiment it has been found that the antimicrobial preservative efficiency of the test samples correspond to the requirements of criterion “A” in accordance with the State Pharmacopoeia of Ukraine, section 5.1.3. The efficiency of the preservative action of the samples at the level of the samples with the additional content of nipagin and nipazol (in the ratio of 2:1) allows not to include additional antimicrobial preservatives in their composition.