SUMMARY
A high level of antibiotic resistance of representatives of Escherichia, Proteus, Klebsiella, Shigella and Salmonella genus makes urgent and prospective the search of new substances that are active in relation to these microorganisms. For the first time the antibacterial activity of lipophilic complexes of biologically active substances (BAS) from bedstraw species of the Ukrainian flora in relation to 11 test strains of Enterobacteriaceae family has been found. The lipophilic complex of Galium cruciata herb (Cruciata laevipez) revealed the highest activity against the test cultures. Microorganisms of Escherichia, Klebsiella and Salmonella genus were highly sensitive (MIC was 31.25 µg/ml; MBC was 62.5 µg/ml), test strains of Proteus and Shigella showed a moderate sensitivity to this lipophilic complex (MIC – 125 µg/ml; MBC – 250 µg/ml). All the test strains revealed a low sensitivity to the lipophilic complexes of BAS from Galium verum and Galium salicifolium herbs. The range of microorganisms sensitivity can be an indirect argument for systematic transfer of cruciform bedstraw to Cruciata genus under the name of Cruciata laevipez.