SUMMARY
The clinical care of the intoxicated, as well as the epidemiological surveillance activities of the population exposed to pesticides, require reference values ??to be able to make decisions based on science. Cholinesterases are biomarkers discovered in the early twentieth century that currently work as auxiliaries in the diagnosis of acute and chronic poisoning. Methodology: In this study we will review 28 investigations that used as a biomarker the cholinesterase in pesticide poisoning, found in search engines PubMed, Dialnet, Redalyc, Crossreff and Google Scholar. Results: 71.42% of the articles reported a decrease in cholinesterase in the population under study and 28.57% report not having detected a decrease in cholinesterase in the study population. Conclusions: We recommend that researchers always consider the delicacy of these enzymes and remember the most important factors that can affect cholinesterase values ??in addition to pesticides.