SUMMARY
The purpose of the research in this article is to justify the need for screening genotyping when selecting candidates for work in extreme conditions. Materials and methods: analysis of literature sources on genetics, psychology, and occupational safety; Russian and international biomedical and genetic databases; protocols and reports of accident investigation, accidents, and catastrophes. Results. Based on the analysis of literature data, protocols of investigation of the causes of air crashes, accidents on highways, mines, chemical enterprises, etc., it can be concluded that many causes of accidents, accidents and catastrophes caused by the so-called "human factor" can be eliminated or leveled with proper organization of psychophysiological testing during professional selection, appropriate physical and psychophysiological training of employees. However, one of the key reasons for reducing occupational safety in extreme conditions is almost impossible to correct, since it is genetically determined. This is fatigue, the degree and speed of development of which when performing professional activities directly depend on endurance. No amount of training can increase endurance above a genetically determined level, and therefore can not reduce the speed and degree of fatigue. You can only reduce the subjective feeling of fatigue – fatigue. But at the same time, fatigue remains, and hidden, which significantly increases the risk of inappropriate reactions and erroneous actions in the event of danger and, ultimately, leads to an accident, a catastrophe. It is shown that at the stage of professional selection, the determination of alleles is sufficient as screening indicators of an increased risk of fatigue D, 34?, S and 3R gene ???, AMPD1, 5HTT and ???? associated with General, physical, and neuropsychic endurance, respectively. Conclusions. 1. screening genotyping of candidates for work in extreme conditions in order to identify nucleotide polymorphisms associated with endurance-fatigue is a key condition for improving labor safety by preemptively reducing the role of the "human factor" in the occurrence of accidents, accidents and catastrophes in hazardous industries. 2. identification of alleles is sufficient as screening indicators of an increased risk of fatigue when working in extreme conditions D, 34?, S and 3R gene ???, AMPD1, 5??? and ????, accordingly, they are associated with an increased risk of rapid development of General, physical and neuropsychiatric fatigue