SUMMARY
The biopermeability of glycyram, a biologically active substance from Glycyrrhiza glabra root was studied in the Problem Laboratory of Morphofunctional Studies of the National University of Pharmacy. Glycyram is a triterpene glycoside with a wide range of the pharmacological activity. However, the intensity of the activity depends on many pharmacokinetic characteristics of the drug, in particular on its bioavailability. Bioavailability in pharmacology reflects the ability of a medicinal substance to be absorbed in the body. It is generally assumed that passing drugs through the intestinal epithelium (a monolayer of cells) is a major barrier to the drug in its pathway into the circulatory system. The bioavailability of the glycyram substance was determined in vitro on a Caco-2 cell model reproducing most of the properties and characteristics of differentiated intestinal epithelial cells. The biopharmaceutical classification system (BCS) for active substances has been put into practice in the pharmaceutical sector of Ukraine. According to the existing BCS, the active substances are divided into 4 classes by their solubility in different media and permeability.