SUMMARY
Zarichna O. Y., Klishch I. M., Krynytska I. Ya. ??????????? ????????? ????? ??????? ??????? ? ????? ? ??????? ????????? ?? ??? ??????????-???????????? ??????????? = Cellular features of the immune system of rats with acute hepatitis combined with merkazolil-induced hypothyroidism. Journal of Education, Health and Sport. 2015;5(8):85-90. ISSN 2391-8306. DOI 10.5281/zenodo.27248http://dx.doi.org/10.5281/zenodo.27248https://pbn.nauka.gov.pl/works/604305POL-index https://pbn.nauka.gov.pl/polindex/browse/article/article-fa2ae17c-9ef3-4fcb-bf3f-8baf66fb89c5http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%288%29%3A85-90Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartosc merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacja MNiSW z dnia 2 czerwca 2014 r., ze w roku 2014 nie bedzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.06.2015. Revised 15.07.2015. Accepted: 25.07.2015. ??? [612.017.1-02:616.36-002.1-06:616.441-008.64]-092.9 ??????????? ????????? ????? ??????? ??????? ? ????? ? ??????? ????????? ?? ??? ??????????-???????????? ???????????CELLULAR FEATURES OF THE IMMUNE SYSTEM OF RATS WITH ACUTE HEPATITIS COMBINED WITH MERKAZOLIL-INDUCED HYPOTHYROIDISM O. Y. Zarichna, I. M. Klishch, I. Ya. Krynytska??????? ?. ?., ???? ?. ?., ????????? ?. ?. ???? «?????????????? ????????? ???????? ??????????? ????? ?. ?. ?????????????? ??? ???????»SHEI "Ternopil State Medical University by I. Ya Horbachevsky of MPH of Ukraine" ??????. ? ???????????? ?? ????? ? ???????????? ????????????, ??????? ???????????????? ????????? ?? ??????? ????????? ?? ??? ??????????? ????????? ??????????? ???? ?????????? ?????????? ????????? ? ?????. ?????????? ??????????? ??????????? ???????? ?? ???????? ????????? ? ???? ????????? ????? ????????? ????? ? ??????? ?-??????????????, ?????????? ???????????????? ?????? ?-?????????? ? ?????????? ?????????? ?-????????, ????????? ?????????????????? ??????? ?? ???????? ?????? ????????? ?-?????????? ? ?????? ? ????????????. ?-??????????, ????????? ???????????????? ?????? ?-?????????? ? ?????????? ??????????? ?-????????, ?????????? ?????????????????? ??????? ?? ?????????? ?????? ????????? ?-?????????? ??????????? ? ?????? ? ??????? ?????????. ?????????????? ??????????? ????????? ????? ????????? ??????? ???? ? ??????? ????????? ?? ??? ???????????. ??????? ?????: ??????? ???????, ??????????, ????????? ????????. SUMMARY. In experiments on rats with modulated hypothyroidism, acute galactosamine hepatitis, acute hepatitis combined with merkazolil- induced hypothyroidism the changes in the indexes of cellular immunity in blood were studied. Results of the investigation indicate a pronounced imbalance of blood cellular immunity in the form of T-lymphocytopenia, imbalance subpopulation of T-lymphocytes with a predominant decreasing in T-helper cells, reducing the immunoregulatory index and decreasing of total B-lymphocytes in rats with hypothyroidism. T-lymphocytosis, imbalance subpopulation of T-lymphocytes with a predominant increasing in T-helper cells, increasing of immunoregulatory index and increasing of B-lymphocytes was determined in rats with acute hepatitis. Rats with acute hepatitis combined with merkazolil- induced hypothyroidism had the most significant suppression of cellular immunity. Key words: acute hepatitis, hypothyroidism, cellular immunity.