SUMMARY
A risk–based approach to the quality of clinical trial (CT) data provides the appropriate conditions for the use of materials at clinical trial site (CTS). One of the most important parameters requires careful monitoring of the temperature mode for storing samples. In case of any temperature failure there can be the data loss that may affect quality of any CT. The procedure of temperature mapping enables to confirm the uniformity and stability parameters of the temperature distribution within the freezers at CTS.Aim. To analyze the guidelines regulating the quality of CT and develop a standard operating procedure (SOP) of the mapping process for freezing equipment at the CTS.Materials and methods. At the Clinical and Diagnostic Center (CDC) of the NUPh the temperature mapping was performed according to the requirements of the WHO in order to prevent risks associated with temperature fluctuations in storage areas of biological samples. This procedure is quite important for the further installation of portable temperature registration systems (data loggers), which are necessary to monitor the temperature regime during CT.Results. At the moment, the documents regulating the mapping procedure are relevant for pharmaceutical manufacturing. However, continuous scientific and technical development, as well as automation of equipment requires the development and implementation of the mapping process into the CT process. Temperature mapping is carried out through a number of requirements, which are partially mentioned in various guidelines on the quality of medical products and the operation of freezing equipment at CTS – guidelines of good practices: Good Clinical Laboratory Practice (GCLP), Good Manufacturing Practice (GMP), Good Storage Practice (GSP), Good Distribution Practice (GDP) and Good Automated Manufacturing Practice (GAMP). The latest 2012th edition of the International Society for Pharmaceutical Engineering (ISPE) GAMP–5 is a set of guidelines for manufacturers and users of automated systems in the pharmaceutical industry. All of these good practices establish the mapping procedure as a required part of the operational and performance qualifications of the freezing equipment used to store drugs in manufacturing, storage facilities and during their transportation, particularly as a part of the “cold chain”. As far as properly calibrated freezing equipment is used during the CT, mapping can also be considered as part of the qualification in a regulatory procedure at CTS. We have developed SOP, which determines the requirements and the algorithm for conducting the mapping procedure at CTS.