SUMMARY
Ziablitsev S. V., Pankiv V. I., Yuzvenko T. Y. ????? ???????????? rs1137101 ???? ????????? ??????? ?? ???????? ????????? ??????? 2 ???? ?? ???????? ? ????? ?????? = Influence of polymorphism rs1137101 of the leptin receptor gene on diabetes mellitus 2 types development. Journal of Education, Health and Sport. 2016;6(4):503-514. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.61750http://ojs.ukw.edu.pl/index.php/johs/article/view/3844 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.04.2016. Revised 25.04.2016. Accepted: 28.04.2016. ????? ???????????? rs1137101 ???? ????????? ????????? ???????? ????????? ??????? 2 ?????? ???????? ? ????? ?????? ?. ?. ????????, ?. ?. ???????, ?. ?. ??????? ??????????? ???????-?????????? ????? ??????????? ????????, ?????????????? ??????????? ??????? ? ?????? ??? ???????, ?. ???? ???????????? ?????? ??????????? ???? ???????? ???? ???????????? rs1137101 ???? LEPR ? ???????? ????????? ??????? 2 ???? ? ???? ?????? ?? ???????-??????????? ?????????, ???'????? ? ????????? ? ??? ??????. ?????????? 103 ???????? ? ????????? ??2, ??? ???? ???????? ???????? ???????????. ?????????? ????? ?????? 100 ????????? ???????? ???? ? ???????????? ????. ?????? ??????????? ???-??????? ??????????? ??????? ???????????? ?????????? ??????? ? ????????? ???? (TaqMan® SNP Genotyping Assay). ?????????? ????????, ?? ???????? ??????????? rs1137101 (223Gln>Arg) ??? ???????????? ? ????????? ????????? ??????? 2 ????: ????? Gln ????????, ? ????? Arg – ?????? (OR=1,55; p=0,030) ????? ???? ????????. ????????? ????? G ? ?????? ? ???????? ?????? ???????? ???????? ?? ???? ???????, ? ???? – ????? ??????? ????????? ???? ???? ?? ??????? ???? ????, ? ????? ???????? ????? ? ????? ???????, ????????????? ?? ????????????? ?????? ????????? ?? ??? ????????? ?????? ????????????? ??????? ?????????. ????? ???????? ???????? ? ????? ?????? ????????? ? 2,8 ?????.??????? ?????: ???????? ?????? 2 ????, ??? ????????? ???????, rs1137101 ??????? ???????????? rs1137101 ???? ????????? ??????? ?? ???????? ????????? ??????? 2 ???? ?. ?. ????????, ?. ?. ???????, ?. ?. ??????? ?????????? ??????-???????????? ????? ??????????? ????????, ?????????????? ??????????? ??????? ? ?????? ?? ???????, ???? ???????????? ??????? ???????????? ???? ???????? ???? ???????????? rs1137101 ???? LEPR ? ???????? ????????? ??????? 2 ???? ? ??? ??????? ?? ???????-???????????? ??????????, ????????? ? ????????? ? ???? ???????. ??????????? 103 ????????, ??????? ????? ?????????? ?????????? ??????????. ??????????? ?????? ????????? 100 ??????????? ???????? ??????? ???????????????? ????????. ?????? ??????????? ???-??????? ???????????? ??????? ???????????? ?????? ??????? ? ???????? ??????? (TaqMan® SNP Genotyping Assay). ?????????? ????????, ??? ????????? ??????????? rs1137101 (223Gln>Arg) ??? ???????????? ? ????????? ????????? ??????? 2 ????: ?????? Gln ????????, ? ?????? Arg – ??????? (OR=1,55; p=0,030) ???? ??? ????????. ??????? ?????? Gln ? ??????? ? ???????? ???????????? ???????? ???????? ? ??? ??????????, ? ?????? – ????? ??????? ????????? ????? ???? ? ??????? ????? ????, ? ????? ???????? ?????? ? ????? ???????, ????????????? ? ????????????? ?????? ????????? ?? ???? ?????????? ?????????? ????????????? ??????? ?????????. ???? ???????? ???????? ? ???? ??????? ??????? ? 2,8 ????.???????? ?????: ???????? ?????? 2 ????, ??? ????????? ???????, rs1137101 INFLUENCE OF POLYMORPHISM rs1137101 OF THE LEPTIN RECEPTOR GENE ON DIABETES MELLITUS 2 TYPES DEVELOPMENT S. V. Ziablitsev, V. I. Pankiv, T. Y. Yuzvenko Ukrainian Scientific-Practical Center of Endocrine Surgery, Transplantation of endocrine organs and tissues of the Ministry of Health of Ukraine, Kiev AbstractThe aim of this research was a study of gene LEPR polymorphism rs1137101 role in diabetes mellitus 2 type development and his influences on the clinical and laboratory data, related to obesity for these patients. 103 patients are inspected, that had the clinically expressed complications. A control group was made by 100 practically healthy persons of corresponding age. The analysis of polymorphic DNA-loci was carried out by the method of polymerase chain reaction in real time (TaqMan® SNP Genotyping Assay). Results showed that allelic polymorphism of rs1137101 (223Gln>Arg) had been associated with diabetes mellitus 2 types development: allele Gln promotes, while allele Arg – reduces (OR=1,55; p=0,030) the risk of its development. Presence allele Gln for diabetic patients assists development of obesity and his displays, namely – to the higher values of weight, body mass index and also to the greater leptin, triglycerides and low-density lipoproteides blood levels on a background reduction of high-density lipoproteides maintenance. The obesity risk for these patients was increased in 2,8 times.Keywords: diabetes mellitus 2 types, leptin receptor gene, rs1137101