SUMMARY
Gozhenko A I, Naumenko O Y. ?????????????? ? ???????????? ????????? ??????????? ????????? ????????? ????? ??????? ? ?????????? ????????? = Metabolic and autoimmune correlates of brain’s structural changes in disseminated sclerosis patients. Journal of Education, Health and Sport. 2015;5(1):163-170. ISSN 2391-8306. DOI: 10.5281/zenodo.14792http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%281%29%3A163-170https://pbn.nauka.gov.pl/works/533080http://dx.doi.org/10.5281/zenodo.14792Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartosc merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacja MNiSW z dnia 2 czerwca 2014 r., ze w roku 2014 nie bedzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 20.10.2014. Revised 18.01.2015. Accepted: 25.01.2015. ?????????????? ? ???????????? ????????? ??????????? ????????? ????????? ????? ??????? ? ?????????? ????????? METABOLIC AND AUTOIMMUNE CORRELATES OF BRAIN’S STRUCTURAL CHANGES IN DISSEMINATED SCLEROSIS PATIENTS ?.?. ???????, ?.?. ????????AI Gozhenko, OY Naumenko ?????????? ??? ???????? ??????????, ?.??????, ???????Ukrainian Research Institute of Medical Transport, Odessa, Ukrainebadiuk_ns@ukr.net ???????????? ?? ????????? ?????? ???????????? ???????????? 64 ???????, ? ???????, ?? ????????? ???????-???????????????? ????????????, ?????????????? ?????????? ???????, ??????? ????? ????? ???????????? ??????????? ????????? ????? ? ?????????? ????? ??????? ??????? ? ?????????????? ????????????? ????????. ????????, ??? ??????????? ????????? ????????? ????? ?? ??????? ? ??????????????? ????????????? ???????, ?? ?????? ?????????????? ????????? ??????????? ??????? ??????? ? ???????? ?????????????????????? ?????????????. ?????? ?????????, ??? ???????? ???? ????????? ??????????? ??????????? ? ????????????? ????????. ?????? ????????, ??? ????????? ? ?????????? ????? ??????? ??????? ???????????? ????????????? ????????????? ????????, ??????? ???????????? ??????????? ??????????? ?????. ?????????? ????????????? ? ???????????? ????????? ? ???????? ???????????, ?? ?????? ??????, ???????????? ?????????? ??????????? ????? ? ?????????? ?????????????? ????????? ? ???. ???????? ?????: ?????????? ???????, ??????? ???????, ??????????? ??????????? ?????. AbstractClinical-and-neurological examination of 64 patients proved the diagnosis of disseminated sclerosis (DS). The relation between brain’s structural changes (BSC), uric acid cycle and autoimmune process intensity has been studied in the group under observation. It has been revealed that BSC have no connection with sexual and age peculiarities of the patients and are always followed by the decreased content of uric acid and the presence of myelin-associated glycoprotein. The amount of the two latter in indexes correlates with the process time duration. The Authors suppose that uric acid cycle changes promote the appearance of autoimmune process which in its turn confers BSC. Aggravation of biochemical and autoimmune disturbances in the dynamics of the disease leads to brain’s disorders preservation and levels its compensatory changes. Key words: disseminated sclerosis, uric acid, structural changes of brain.